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Although familial forms of the disease exist, the cause of sporadic PD is unknown. Symptomatic treatments are available for PD, but there are no disease modifying therapies. While the neurodegenerative processes in PD may be multifactorial, this paper will review the evidence that prooxidant iron elevation in the SNc is an invariable feature of sporadic and familial PD forms, participates in the disease mechanism, and presents as a tractable target for a disease modifying therapy.<\/jats:p>","DOI":"10.1155\/2014\/581256","type":"journal-article","created":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T04:25:43Z","timestamp":1390105543000},"page":"1-9","source":"Crossref","is-referenced-by-count":152,"title":["Nigral Iron Elevation Is an Invariable Feature of Parkinson\u2019s Disease and Is a Sufficient Cause of Neurodegeneration"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3479-2427","authenticated-orcid":true,"given":"Scott","family":"Ayton","sequence":"first","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building at Genetics Lane on 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