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We first identified the genes that are differentially expressed in the femur between female and male in<jats:italic>sfx<\/jats:italic>mice. We then analyzed the potential gene network among those differentially expressed genes with whole genome expression profiles generated using spleens of female and male mice of a total of 67 BXD (C57BL\/6J X DBA\/2J) recombinant inbred (RI) and other strains. Our result indicated that there was a sex difference in the whole genome profiles in<jats:italic>sfx<\/jats:italic>mice as measured by the proportion of up- and downregulated genes. Several genes in the pathway of bone development are differentially expressed between the male and female of<jats:italic>sfx<\/jats:italic>mice. Comparison of gene network of up- and downregulated bone relevant genes also suggests a sex difference.<\/jats:p>","DOI":"10.1155\/2014\/584910","type":"journal-article","created":{"date-parts":[[2014,7,14]],"date-time":"2014-07-14T17:05:43Z","timestamp":1405357543000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Genome Wide Analysis of Sex Difference in Gene Expression Profiles of Bone Formations Using<i>sfx<\/i>Mice and BXD RI Strains"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yue","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and BME, University of Tennessee Health Science Center, 956 Court Avenue, Memphis, TN 38163, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Mudanjiang Medical College, Tongxiang Road, Aimin District, Mudanjiang City, Heilongjiang 157001, 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