{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:20:57Z","timestamp":1774610457428,"version":"3.50.1"},"reference-count":6,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,3,6]],"date-time":"2014-03-06T00:00:00Z","timestamp":1394064000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2014,3,6]]},"abstract":"<jats:p>A simple protocol for the efficient preparation of <jats:italic>\u03b2<\/jats:italic>-mercapto carbonyl derivatives as antimycobacterial drugs has been achieved via Thia-Michael reaction between chalcones derivatives and thiols in the presence of calcium pyrophosphate as a heterogeneous catalyst under mild reaction conditions. The central composite design was used to design an experimental program to provide data to model the effects of various factors on reaction yield <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>Y<\/mml:mi><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. The variables chosen were catalyst weight <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:msub><mml:mrow><mml:mi>X<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>1<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>, reaction time <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:msub><mml:mrow><mml:mi>X<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>, and solvent volume <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:msub><mml:mrow><mml:mi>X<\/mml:mi><\/mml:mrow><mml:mrow><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>. The mathematical relationship of reaction yield on the three significant independent variables can be approximated by a nonlinear polynomial model. Predicted values were found to be in good agreement with experimental values. The optimum reaction conditions for reaction model (chalcone and thiophenol) obtained by response surface were applied to other substrates. This procedure provides several advantages such as high yield, clean product formation, and short reaction time.<\/jats:p>","DOI":"10.1155\/2014\/586437","type":"journal-article","created":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T09:22:46Z","timestamp":1394356966000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Experimental Design-Based Response Surface Methodology Optimization for Synthesis of <i>\u03b2<\/i>-Mercapto Carbonyl Derivatives as Antimycobacterial Drugs Catalyzed by Calcium Pyrophosphate"],"prefix":"10.1155","volume":"2014","author":[{"given":"Younes","family":"Abrouki","sequence":"first","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkader","family":"Anouzla","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayat","family":"Loukili","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamal","family":"Bennazha","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia\u00e2","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Rayadh","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"My Abdellah","family":"Bahlaoui","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa\u00efd","family":"Sebti","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Ben M'Sik, University Hassan II, Casablanca 20455, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Driss","family":"Zakarya","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Zahouily","sequence":"additional","affiliation":[{"name":"Department of Research, Faculty of Science and Technology, University Hassan II, Mohammedia 20652, Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2011.07.022"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(02)02146-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1080\/00397910903291129"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.11648\/j.ajac.20130102.12","volume":"1","year":"2013","journal-title":"American Journal of Applied Chemistry"},{"issue":"4","key":"7","first-page":"1","volume":"1","year":"2013","journal-title":"Open Research Journal of Statistical Design and Analysis"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S1381-1169(03)00208-5"}],"container-title":["International Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/586437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/586437.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/586437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T18:26:45Z","timestamp":1607538405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ijmc\/2014\/586437\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,6]]},"references-count":6,"alternative-id":["586437","586437"],"URL":"https:\/\/doi.org\/10.1155\/2014\/586437","relation":{},"ISSN":["2090-2069","2090-2077"],"issn-type":[{"value":"2090-2069","type":"print"},{"value":"2090-2077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,6]]}}}