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Despite the significant progress in chemotherapeutic advancements, there is still need for other measures like development of an effective vaccine or discovery of novel drug targets. In this study, structural and immunological characterization of independent phosphoglycerate mutase of filarial parasite<jats:italic>Brugia malayi<\/jats:italic>was carried out. Protein was found to be expressed in all major parasite life stages and as an excretory secretory product of adult parasites. Bm-iPGM also reacted to all the categories of human bancroftian patient\u2019s sera including endemic normals.<jats:italic>In vivo<\/jats:italic>immunological behaviour of protein was determined in immunized BALB\/c mice followed by prophylactic analysis in BALB\/c mice and<jats:italic>Mastomys coucha<\/jats:italic>. Immunization with Bm-iPGM led to generation of a mixed Th1\/Th2 type immune response offering 58.2% protection against larval challenge in BALB\/c and 65\u201368% protection in<jats:italic>M. coucha<\/jats:italic>.<jats:italic>In vitro<\/jats:italic>studies confirmed participation of anti-Bm-iPGM antibodies in killing of<jats:italic>B. malayi<\/jats:italic>infective larvae and microfilariae through ADCC mechanism. The present findings reveal potential immunoprotective nature of Bm-iPGM advocating its worth as an antifilarial vaccine candidate.<\/jats:p>","DOI":"10.1155\/2014\/590281","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T08:54:48Z","timestamp":1404291288000},"page":"1-19","source":"Crossref","is-referenced-by-count":18,"title":["Cofactor Independent Phosphoglycerate Mutase of<i>Brugia malayi<\/i>Induces a Mixed Th1\/Th2 Type Immune Response and Inhibits Larval Development in the Host"],"prefix":"10.1155","volume":"2014","author":[{"given":"Prashant K.","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Parasitology, CSIR-Central Drug Research Institute, B.S. 10\/1, Sector 10, P.O. 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