{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T22:58:10Z","timestamp":1780613890480,"version":"3.54.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:00:00Z","timestamp":1419379200000},"content-version":"vor","delay-in-days":357,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:italic>Flos Lonicerae<\/jats:italic> is one of the oldest and most commonly prescribed herbs in Eastern traditional medicine to treat various inflammatory diseases. In the present study, we investigated the effects of ethyl acetate fraction of <jats:italic>Flos Lonicerae<\/jats:italic> (GC\u20107101) on experimental gastric ulcer models and its mechanisms of action in gastric ulcer healing. The pharmacological activity of GC\u20107101 was investigated in rats on HCl\/EtOH, indomethacin, water immersion restraint stress induced acute gastric ulcer, and acetic\u2010acid\u2010induced subchronic gastric ulcer. To determine its gastroprotective mechanisms, gastric wall mucus secretion, mucosal PGE<jats:sub>2<\/jats:sub>, mucosal NO content, nuclear translocation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B, mRNA expression of inflammatory cytokines, lipid peroxidation and glutathione content, and superoxide dismutase and catalase activities were measured. GC\u20107101 significantly attenuated development of acute gastric ulcer and accelerated the healing of acetic\u2010acid\u2010induced subchronic gastric ulcer. In HCl\/EtOH\u2010induced gastric ulcer, GC\u20107101 markedly enhanced gastric wall mucus content which was accompanied by increased mucosal PGE<jats:sub>2<\/jats:sub> and NO production. Furthermore, treatment of GC\u20107101 exhibited anti\u2010inflammatory and antioxidant activities as evidenced by decreased myeloperoxidase activity, NF\u2010<jats:italic>\u03ba<\/jats:italic>B translocation, inflammatory cytokines mRNA expression, and lipid peroxidation and increased glutathione content  and superoxide dismutase and catalase activities. These results demonstrated that GC\u20107101 possesses strong antiulcerogenic effect by modulating oxidative stress and proinflammatory mediators.<\/jats:p>","DOI":"10.1155\/2014\/596920","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T21:03:56Z","timestamp":1419455036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Protective Effect of <i>Flos Lonicerae<\/i> against Experimental Gastric Ulcers in Rats: Mechanisms of Antioxidant and Anti\u2010Inflammatory 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