{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:24:54Z","timestamp":1789568694281,"version":"build-2803163510"},"reference-count":21,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. In this study, we aimed to demonstrate the correlation of FGF-23 levels with bone-mineral metabolism, anemia, and the treatment in dialysis patients.<jats:italic>Methods<\/jats:italic>. Eighty-nine patients with similar age, gender, dialysis duration, and dialysis adequacy who were receiving hemodialysis replacement therapy for at least 6 months were included in the study. Serum iron, iron binding capacity, ferritin, hemoglobin (Hb), hematocrit (Htc), calcium (Ca), phosphorus (P), intact parathormone (iPTH), and FGF-23 levels were studied. In addition, active vitamin D and phosphate binders calcimimetic therapies that patients have received in the last 6 months were recorded.<jats:italic>Results<\/jats:italic>. It was determined that there was a positive correlation between serum FGF-23 values and PTH values (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>,<\/mml:mo><mml:mi>\uef22<\/mml:mi><mml:mn>01<\/mml:mn><\/mml:math>) and Ca<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>*<\/mml:mi><\/mml:mrow><\/mml:math>P values (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>,<\/mml:mo><mml:mi>\uef22<\/mml:mi><mml:mn>01<\/mml:mn><\/mml:math>). A positive correlation was found between serum FGF-23 values and Ca values at a rate of 24,6% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>,<\/mml:mo><mml:mi>\uef22<\/mml:mi><mml:mn>05<\/mml:mn><\/mml:math>) and between<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>values at a rate of 59,1% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>,<\/mml:mo><mml:mi>\uef22<\/mml:mi><mml:mn>01<\/mml:mn><\/mml:math>). A positive correlation was determined between serum FGF-23 values and hemoglobin (Hb) values (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>,<\/mml:mo><mml:mi>\uef22<\/mml:mi><mml:mn>05<\/mml:mn><\/mml:math>) and hematocrit (Htc) values (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>,<\/mml:mo><mml:mi>\uef22<\/mml:mi><mml:mn>05<\/mml:mn><\/mml:math>). In multivariate analysis, no significant correlation was found between serum FGF-23 levels and Hb and Htc.<jats:italic>Conclusion<\/jats:italic>. The effects of high serum FGF-23 levels on different parameters may be correlated with the development of refractory secondary hyperparathyroidism.<\/jats:p>","DOI":"10.1155\/2014\/602034","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T21:00:55Z","timestamp":1410382855000},"page":"1-6","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic Importance of Fibroblast Growth Factor-23 in Dialysis Patients"],"prefix":"10.1155","volume":"2014","author":[{"given":"Nilg\u00fcl","family":"Akalin","sequence":"first","affiliation":[{"name":"Department of Nephrology, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y\u0131ld\u0131z","family":"Okuturlar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Bak\u0131rk\u00f6y Dr. Sadi Konuk Training and Research Hospital, Istanbul 34147, 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