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The cryptochrome-null mice received high-salt treatment and were treated orally with 4HCH 10\u2009mg\/kg, 4HCH 20\u2009mg\/kg, and 4HCH 40\u2009mg\/kg, respectively. The salt administration in cryptochrome-null mice is able to induce an increase in systolic pressure which is associated with hyperaldosteronism, inflammation, and kidney injury. Treatment with 40\u2009mg\/kg 4HCH reduced systolic hypertension, serum IL-1<jats:italic>\u03b2<\/jats:italic>, and TNF-<jats:italic>\u03b1<\/jats:italic>levels and suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-<jats:italic>\u03ba<\/jats:italic>B) and renal injury. The impact of 4HCH on the hyperaldosteronism, inflammation, and kidney injury provides new insights for future development of therapeutic strategies in resistant hypertension.<\/jats:p>","DOI":"10.1155\/2014\/603415","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T17:21:18Z","timestamp":1402334478000},"page":"1-5","source":"Crossref","is-referenced-by-count":8,"title":["4-Hydroxychalcone Attenuates Hyperaldosteronism, Inflammation, and Renal Injury in Cryptochrome-Null Mice"],"prefix":"10.1155","volume":"2014","author":[{"given":"Qi","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, The Fourth People\u2019s Hospital of Jinan City, Jinan 250031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingguang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The Fourth People\u2019s Hospital of Jinan City, Jinan 250031, 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