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This study aims to investigate acupuncture\u2010induced changes in effective connectivity among motor areas in hemiparetic stroke patients by using the multivariate Granger causal analysis. A total of 9 stable recovery stroke patients and 8 healthy controls were recruited and underwent three runs of fMRI scan: passive finger movements and resting state before and after manual acupuncture stimuli. Stroke patients showed significantly attenuated effective connectivity between cortical and subcortical areas during passive motor task, which indicates inefficient information transmissions between cortical and subcortical motor\u2010related regions. Acupuncture at motor\u2010implicated acupoints showed specific modulations of motor\u2010related network in stroke patients relative to healthy control subjects. 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