{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:31:25Z","timestamp":1778607085013,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T00:00:00Z","timestamp":1397088000000},"content-version":"vor","delay-in-days":99,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["NSC102-2314-B-039-025"],"award-info":[{"award-number":["NSC102-2314-B-039-025"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["DOH102-TD-B-111-004"],"award-info":[{"award-number":["DOH102-TD-B-111-004"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Taiwan Department of Health Clinical Trial and Research Center of Excellence","award":["NSC102-2314-B-039-025"],"award-info":[{"award-number":["NSC102-2314-B-039-025"]}]},{"name":"Taiwan Department of Health Clinical Trial and Research Center of Excellence","award":["DOH102-TD-B-111-004"],"award-info":[{"award-number":["DOH102-TD-B-111-004"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Topical traditional Chinese medicine\u2010 (TTCM\u2010) related contact dermatitis is not uncommon but ignored. Patch and photopatch tests using 6 individual herbal ingredients and Bai\u2010Zhi\u2010Kao (BZK; <jats:italic>\u767d<\/jats:italic><jats:italic>\u82b7<\/jats:italic><jats:italic>\u818f<\/jats:italic>), a skin\u2010lightening TTCM preparation, were conducted on 30 participants. Twenty\u2010five subjects showed at least 1 positive reaction, including 6 (20.0%) participants who reacted to BZK. The majority reacted to Radix <jats:italic>Ampelopsis japonica<\/jats:italic> (Bai\u2010Lian; <jats:italic>\u767d<\/jats:italic><jats:italic>\u861e<\/jats:italic>) (60.0%), whereas few reacted to Rhizoma Bletilla striata (Bai\u2010Ji; <jats:italic>\u767d<\/jats:italic><jats:italic>\u82a8<\/jats:italic>) (16.7%), Rhizoma <jats:italic>Atractylodis macrocephalae<\/jats:italic> (Bai\u2010Zhu; <jats:italic>\u767d<\/jats:italic><jats:italic>\u672e<\/jats:italic>) (10.0%), Radix <jats:italic>Angelicae dahuricae<\/jats:italic> (Bai\u2010Zhi; <jats:italic>\u767d<\/jats:italic><jats:italic>\u82b7<\/jats:italic>) (3.3%), and Herba asari (Xi\u2010Xin; <jats:italic>\u7d30<\/jats:italic><jats:italic>\u8f9b<\/jats:italic>) (3.3%). In the photopatch test, 3 participants (10.0%) reacted positively to BZK and 10 to \u22651 constituent; however, all reacted to Radix <jats:italic>Angelicae dahuricae<\/jats:italic> (26.7%), Radix <jats:italic>Ampelopsis japonica<\/jats:italic> (13.3%), and Rhizoma Bletilla striata (3.3%). In contrast, no subjects showed positive reactions to Sclerotium Poria cocos (Bai\u2010Fu\u2010Ling; <jats:italic>\u767d<\/jats:italic><jats:italic>\u832f<\/jats:italic><jats:italic>\u82d3<\/jats:italic>). Thus, BZK and its constituents might present potential latent risk of contact dermatitis owing to the possible presence of Radix  <jats:italic>Ampelopsis japonica<\/jats:italic> and Radix <jats:italic>Angelicae dahuricae<\/jats:italic>. Furthermore, TTCMs, particularly cosmetic products, must be used carefully, with ample warning of potential contact dermatitis risk.<\/jats:p>","DOI":"10.1155\/2014\/609064","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T21:03:31Z","timestamp":1397163811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Irritant Contact Dermatitis Risk of Common Topical Traditional Chinese Medicines Used for Skin\u2010Lightening: A Pilot Clinical Trial with 30 Volunteers"],"prefix":"10.1155","volume":"2014","author":[{"given":"Kao-Sung","family":"Tsai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Chun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-Tse","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jui-Lung","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Ya","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey-Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-5113","authenticated-orcid":false,"given":"Yung-Hsiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,10]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/739473"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/386734"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/827248"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04497.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(97)00061-8"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.47102\/annals-acadmedsg.V36N11p942"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3123"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.30.719"},{"key":"e_1_2_8_9_2","first-page":"11","article-title":"New cosmetic agents for skin whitening from Angelica dahurica","volume":"57","author":"Cho Y. 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