{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:23:59Z","timestamp":1788870239778,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Education and Science of the Republic of Slovenia","award":["1000-07-310121"],"award-info":[{"award-number":["1000-07-310121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    In infectious synovitis caused by\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    chicken chondrocytes (CCH) may come into direct contact with these bacteria that are also capable of invading CCH\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In this study, phenotype microarrays were used to evaluate the influence of\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    on the global metabolic activity of CCH. Therefore, CCH were cultured in the presence of 504 individual compounds, spotted in wells of 11 phenotype microarrays for eukaryotic cells, and exposed to\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    membranes or viable\n                    <jats:italic>Mycoplasma synoviae.<\/jats:italic>\n                    Metabolic activity and sensitivity of normal cells versus infected cells were evaluated. Metabolic profiles of CCH treated with viable\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    or its membranes were significantly different from those of CCH alone. CCH treated with\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    membranes were able to use 48 carbon\/nitrogen sources not used by CCH alone. Treatment also influenced ion uptake in CCH and intensified the sensitivity to 13 hormones, 5 immune mediators, and 29 cytotoxic chemicals. CCH were even more sensitive to hormones\/immune mediators when exposed to viable\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    . Our results indicate that exposure to\n                    <jats:italic>Mycoplasma synoviae<\/jats:italic>\n                    or its membranes induces a wide range of metabolic and sensitivity modifications in CCH that can contribute to pathological processes in the development of infectious synovitis.\n                  <\/jats:p>","DOI":"10.1155\/2014\/613730","type":"journal-article","created":{"date-parts":[[2014,8,26]],"date-time":"2014-08-26T17:18:00Z","timestamp":1409073480000},"page":"1-10","source":"Crossref","is-referenced-by-count":7,"title":["Phenotypic Characterization of\n                    <i>Mycoplasma synoviae<\/i>\n                    Induced Changes in the Metabolic and Sensitivity Profile of\n                    <i>In Vitro<\/i>\n                    Infected Chicken Chondrocytes"],"prefix":"10.1155","volume":"2014","author":[{"given":"Daliborka","family":"Du\u0161ani\u0107","sequence":"first","affiliation":[{"name":"Department of Animal Science, Biotechnical 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