{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:26:39Z","timestamp":1769603199755,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","award":["VGHKS100-094"],"award-info":[{"award-number":["VGHKS100-094"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. To investigate the impact of blood type, functional polymorphism (T-1676C) of the<jats:italic>COX-1<\/jats:italic>gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.<jats:italic>Methods<\/jats:italic>. In a case-control study including 111 low-dose aspirin users with peptic ulcers and 109 controls (asymptomatic aspirin users), the polymorphism (T-1676C) of the<jats:italic>COX-1<\/jats:italic>gene promoter was genotyped, and blood type,<jats:italic>H pylori<\/jats:italic>status, and clinical factors were assessed.<jats:italic>Results<\/jats:italic>. Univariate analysis showed no significant differences in genotype frequencies of the<jats:italic>COX-1<\/jats:italic>gene at position -1676 between the peptic ulcer group and control group. Multivariate analysis revealed that blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID were the independent risk factors for the development of peptic ulcer with the odds ratios of the 2.1, 3.1, 27.6, and 2.9, respectively.<jats:italic>Conclusion<\/jats:italic>. The C-1676T polymorphism in the<jats:italic>COX-1<\/jats:italic>gene promoter is not a risk factor for ulcer formation during treatment with low-dose aspirin. Blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID are of independent significance in predicting peptic ulcer development during treatment with low-dose aspirin.<\/jats:p>","DOI":"10.1155\/2014\/616018","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T17:03:27Z","timestamp":1409159007000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Impact of Blood Type, Functional Polymorphism (T-1676C) of the<i>COX-1<\/i>Gene Promoter and Clinical Factors on the Development of Peptic Ulcer during Cardiovascular Prophylaxis with Low-Dose Aspirin"],"prefix":"10.1155","volume":"2014","author":[{"given":"Pin-Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of 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