{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:24:41Z","timestamp":1775028281409,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"The SynsLaser Surgery AS"},{"DOI":"10.13039\/501100005416","name":"Norwegian Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. Our main purpose was to compare safety and efficacy in the treatment of progressive keratoconus with \u201cepithelium-on\u201d and \u201cepithelium-off\u201d corneal collagen cross-linking (CXL). Our secondary purpose was to evaluate efficacy of CXL when hypotonic 0.5% riboflavin is used as photosensitizer.<jats:italic>Methods<\/jats:italic>. One eye of 20 patients with bilateral progressive keratoconus was randomly treated for \u201cepithelium-on\u201d CXL (group 1) while the fellow eye underwent \u201cepithelium-off\u201d CXL (group 2). Hypotonic 0.5% riboflavin was used in both groups. Visual acuity, refraction, corneal topography, and wavefront aberrometry were evaluated at baseline and after 1, 6, and 12 months. Specular microscopy was performed on 10 patients preoperatively and after 12 months. Postoperative pain was evaluated using a patient questionnaire.<jats:italic>Results<\/jats:italic>. Uncorrected and corrected distance visual acuity improved significantly in both groups. Refraction, topography, and aberrometry showed nonsignificant changes from the preoperative status throughout the 12-month follow-up in both groups. Moreover, the outcomes between the groups were comparable at all follow-up points. Endothelial cell-count was stable. Postoperative pain length was shorter in group 1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mfenced separators=\"|\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:mfenced><\/mml:mrow><\/mml:math>.<jats:italic>Conclusion<\/jats:italic>. \u201cEpithelium-on\u201d and \u201cepithelium-off\u201d CXL using hypotonic 0.5% riboflavin were equally safe and effective in stabilization of keratoconus. Topography and aberrometry outcomes in both groups failed to show any significant improvements. This study is registered at ClinicalTrials.gov:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/results?term=NCT01181219\">NCT01181219<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2014\/619398","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T06:51:31Z","timestamp":1404802291000},"page":"1-9","source":"Crossref","is-referenced-by-count":51,"title":["Corneal Collagen Cross-Linking with and without Epithelial Removal: A Contralateral Study with 0.5% Hypotonic Riboflavin Solution"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1363-4689","authenticated-orcid":true,"given":"Aleksandar","family":"Stojanovic","sequence":"first","affiliation":[{"name":"SynsLaser Kirurgi AS, 9007 Troms\u00f8, Troms, Norway"},{"name":"Eye Department, University Hospital North Norway, Sykehusveien 38, 9019 Troms\u00f8, Troms, 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