{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T15:56:26Z","timestamp":1765727786278,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":238,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"crossref","award":["2012CB518501","2011SZ0302","12DXYB215JH002"],"award-info":[{"award-number":["2012CB518501","2011SZ0302","12DXYB215JH002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2012CB518501","2011SZ0302","12DXYB215JH002"],"award-info":[{"award-number":["2012CB518501","2011SZ0302","12DXYB215JH002"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chengdu City, China","award":["2012CB518501","2011SZ0302","12DXYB215JH002"],"award-info":[{"award-number":["2012CB518501","2011SZ0302","12DXYB215JH002"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Chronic stable angina pectoris (CSAP) is a major syndrome of ischemic heart disease (IHD). CSAP manifests as chest pain or discomfort and affects patients\u2019 quality of life. Acupoint application (AP) has been reported to be effective for managing the symptoms of CSAP, but the evidence is not convincing. Therefore, we designed a randomized, double\u2010blind, placebo\u2010controlled clinical trial to evaluate the efficacy of AP in the treatment of CSAP. <jats:italic>Methods and Analysis<\/jats:italic>.  Two hundred participants with CSAP will be randomly assigned in a 1\u2009:\u20091\u2009:\u20091\u2009:\u20091 ratio into 4 groups. All participants will receive 12 sessions of treatment in 4 weeks and  the same basic treatment procedure. The participants will be visited and assessed for 12 weeks, including a 4\u2010week screening, a 4\u2010week treatment phase, and a 4\u2010week follow\u2010up phase. The primary outcome is the change in the total frequency of self\u2010reported angina attack at 4th week compared with the baseline. The secondary outcomes include the intensity of angina pain, consumption of nitroglycerin or <jats:italic>Suxiao Jiuxin<\/jats:italic> pills, CCS angina classification, SAQ, SAS and SDS score. <jats:italic>Ethics<\/jats:italic>. The study protocol has been reviewed and approved by the Sichuan Regional Ethics Review Committee on TCM (number 2013kl\u2010001). This trial is registered with  clinicaltrials.gov <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/results?term=NCT02029118\">NCT02029118<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2014\/619706","type":"journal-article","created":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T21:03:24Z","timestamp":1409173404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Acupoint Application in Patients with Chronic Stable Angina Pectoris: Study Protocol of a Randomized, Double\u2010Blind, Controlled Trial"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yulan","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1975-3307","authenticated-orcid":false,"given":"Hui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junling","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyan","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linglin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanrong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,27]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68770-9"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38695.605440.AE"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl001"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.13-1-63"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.08.002"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.12.008"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.10.010"},{"key":"e_1_2_8_8_2","article-title":"Features of complementary and alternative medicine use by patients with coronary artery disease in Beijing: a cross-sectional study","volume":"13","author":"Chu F. 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