{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:06Z","timestamp":1740164586180,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Double hit B-cell lymphomas are rare tumors that are defined by a chromosomal breakpoint affecting the MYC\/8q24 locus in combination with another recurrent breakpoint, mainly a t(14;18)(q32;q21) involving BCL2. These tumors mostly occur in adults and carry a very poor prognosis. Double hit lymphomas can occur de novo, or arise from transformation of follicular lymphoma. We report a case of a 69-year-old female with abdominal distention and progressively worsening weakness over six months. Patient presented with severe hypercalcemia and multiple intra-abdominal\/pelvic masses. Histopathology results of the abdominal mass were compatible with a double hit B-cell lymphoma. However, bone marrow biopsy results showed a low grade follicular lymphoma, thus suggesting peripheral transformation of follicular lymphoma to double hit B-cell lymphoma. Patient was transferred to a tertiary care center and was started on combination chemotherapy (EPOCH: doxorubicin, etoposide, vincristine, cyclophosphamide, and prednisone). Our paper highlights not only transformation of follicular lymphoma to double hit B-cell lymphoma and the challenges encountered in diagnosing and treating these aggressive tumors, but also the association of new onset\/worsening hypercalcemia in such patients.<\/jats:p>","DOI":"10.1155\/2014\/619760","type":"journal-article","created":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T21:54:37Z","timestamp":1407189277000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Transformation of Follicular Lymphoma to Double Hit B-Cell Lymphoma Causing Hypercalcemia in a 69-Year-Old Female: A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-0505","authenticated-orcid":true,"given":"Sakshi","family":"Kapur","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles B.","family":"Levin","sequence":"additional","affiliation":[{"name":"Division of Pathology, Overlook Medical Center, 99 Beauvoir Avenue, Summit, NJ 07902, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12343"},{"issue":"2","key":"2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12013-013-9790-6","volume":"69","year":"2014","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"9","key":"3","first-page":"584","volume":"42","year":"2013","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-297879"},{"issue":"4","key":"5","first-page":"788","volume":"6","year":"2013","journal-title":"International Journal of Clinical and Experimental 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