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From the<jats:italic>in vitro<\/jats:italic>glucose uptake assay, two compounds behaved as insulin sensitizers, where they enhanced glucose uptake in isolated rat diaphragm. In high-carbohydrate diet-induced insulin resistant mice, these two thiazolidin-4-ones attenuated hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and glucose intolerance. They raised the plasma leptin but did not reverse the diabetes-induced hypoadiponectinemia. Additionally, compound<jats:bold>3a<\/jats:bold>reduced adiposity. The test compounds were also able to reverse the disturbed liver antioxidant milieu. To conclude, these two novel thiazolidin-4-ones modulated multiple mechanisms involved in metabolic disorders, reversing insulin resistance and thus preventing the development of type-2 diabetes.<\/jats:p>","DOI":"10.1155\/2014\/620434","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T21:07:19Z","timestamp":1401829639000},"page":"1-14","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder"],"prefix":"10.1155","volume":"2014","author":[{"given":"Vasantharaju S.","family":"Gowdra","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, 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