{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:07:47Z","timestamp":1791248867573,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Skin Cancer"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Although techniques of immunophenotyping have been successful in characterizing the cells in the cutaneous infiltrates of mycosis fungoides little evidence suggests that variations in the phenotypic characterization correlate with prognosis.<jats:italic>Objectives<\/jats:italic>. In a preliminary prospective, single-centre, study we correlated the T-cell phenotype in cutaneous biopsies with the progression of the disease to determine whether the coexpression of CD4 and CD8 has an impact on prognosis.<jats:italic>Methods<\/jats:italic>. Skin biopsy specimens from 30 newly diagnosed patients were stained with immunoperoxidase techniques to determine their phenotypic characteristics. After a median followup of 42 months patients were divided into two groups with stable and progressive disease.<jats:italic>Results<\/jats:italic>. Eighteen patients had the conventional CD4+CD8\u2212 T-cell phenotype. Ten patients showed the coexpression of CD4 and CD8 and had a slightly lower rate of progressive disease.<jats:italic>Conclusions<\/jats:italic>. The coexpression of CD4 and CD8 in cutaneous lesions is not rare and is associated with a slightly lower rate of progressive disease. Since double positive CD4\/CD8 phenotype is rarely reported in mycosis fungoides the presence on conventional immunophenotyping of both CD may be due to a \u201cmixture\u201d of neoplastic cells and inflammatory CD8+ tumor infiltrating lymphocytes. Immunohistochemical study combined with confocal microscopy could clarify this issue.<\/jats:p>","DOI":"10.1155\/2014\/624143","type":"journal-article","created":{"date-parts":[[2014,7,20]],"date-time":"2014-07-20T17:05:31Z","timestamp":1405875931000},"page":"1-4","source":"Crossref","is-referenced-by-count":7,"title":["The Influence of the Coexpression of CD4 and CD8 in Cutaneous Lesions on Prognosis of Mycosis Fungoides: A Preliminary Study"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-7429","authenticated-orcid":true,"given":"Sergio Umberto","family":"De Marchi","sequence":"first","affiliation":[{"name":"Institute of Dermatology and Venereology, University of Trieste, Ospedale Maggiore, Piazza Ospedale 1, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2392-9504","authenticated-orcid":true,"given":"Giuseppe","family":"Stinco","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Department of Experimental and Clinical Medicine, University of Udine, Ospedale San Michele, Piazza Rodolone 1, 33013 Gemona del Friuli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7152-6136","authenticated-orcid":true,"given":"Enzo","family":"Errichetti","sequence":"additional","affiliation":[{"name":"Institute of Dermatology, Department of Experimental and Clinical Medicine, University of Udine, Ospedale San Michele, Piazza Rodolone 1, 33013 Gemona del Friuli, 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