{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T09:44:01Z","timestamp":1769939041422,"version":"3.49.0"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004708","name":"Kementerian Pendidikan Nasional","doi-asserted-by":"publisher","award":["PN-IIID-PCE-2012-4-0067"],"award-info":[{"award-number":["PN-IIID-PCE-2012-4-0067"]}],"id":[{"id":"10.13039\/501100004708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Hypoxia plays an important role in tumour recurrence among head and neck cancer patients. The identification and quantification of hypoxic regions are therefore an essential aspect of disease management. Several predictive assays for tumour oxygenation status have been developed in the past with varying degrees of success. To date, functional imaging techniques employing positron emission tomography (PET) have been shown to be an important tool for both pretreatment assessment and tumour response evaluation during therapy. Hypoxia-specific PET markers have been implemented in several clinics to quantify hypoxic tumour subvolumes for dose painting and personalized treatment planning and delivery. Several new radiotracers are under investigation. PET-derived functional parameters and tracer pharmacokinetics serve as valuable input data for computational models aiming at simulating or interpreting PET acquired data, for the purposes of input into treatment planning or radio\/chemotherapy response prediction programs. The present paper aims to cover the current status of hypoxia imaging in head and neck cancer together with the justification for the need and the role of computer models based on PET parameters in understanding patient-specific tumour behaviour.<\/jats:p>","DOI":"10.1155\/2014\/624642","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T19:02:46Z","timestamp":1408647766000},"page":"1-13","source":"Crossref","is-referenced-by-count":7,"title":["Hypoxia in Head and Neck Cancer in Theory and Practice: A PET-Based Imaging Approach"],"prefix":"10.1155","volume":"2014","author":[{"given":"Loredana G.","family":"Marcu","sequence":"first","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Oradea, 410087 Oradea, Romania"},{"name":"School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5000, Australia"}]},{"given":"Wendy M.","family":"Harriss-Phillips","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics, University of Adelaide, Adelaide, SA 5000, Australia"},{"name":"Department of Medical Physics, Royal Adelaide Hospital, Adelaide, SA 5000, Australia"}]},{"given":"Sanda M.","family":"Filip","sequence":"additional","affiliation":[{"name":"Department of Physics, Faculty of Science, University of Oradea, 410087 Oradea, Romania"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2005.06.038"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/17904358"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(99)00115-7"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00159-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/nature10169"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00677-5"},{"issue":"6b","key":"7","first-page":"4301","volume":"21","year":"2001","journal-title":"Anticancer Research"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80108-7"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601401"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2003.10.024"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1159\/000124293"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.03.004"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-2495"},{"issue":"1","key":"14","first-page":"1","volume":"33","year":"2013","journal-title":"Acta Otorhinolaryngologica Italica"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-0620-8_4"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.2878"},{"issue":"9","key":"32","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s12149-011-0508-9","volume":"25","year":"2011","journal-title":"Annals of Nuclear Medicine"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0424-3"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-009-1154-5"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-008-0742-0"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.053785"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283571016"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-011-0471-5"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0b013e3182a756f0"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/51\/22\/009"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1118\/1.3213092"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.103523"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1093\/imammb\/dqr002"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.05.005"},{"key":"54","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3109\/0284186X.2013.812796","volume":"52","year":"2013","journal-title":"Acta Oncologica"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/56\/7\/009"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1118\/1.4868462"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-85998-9_40"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/53\/17\/001"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/19\/6079"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2007.08.003"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1593\/neo.81360"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.04.012"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2011.599815"},{"key":"16","year":"2012"},{"key":"17","first-page":"145","volume":"106","year":"1968","journal-title":"Scandinavian Journal of Clinical and Laboratory Investigation"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2011.01258.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-006-0431-y"},{"issue":"3","key":"20","first-page":"259","volume":"54","year":"2010","journal-title":"The Quarterly Journal of Nuclear Medicine and Molecular Imaging"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24846"},{"issue":"11","key":"22","first-page":"665","volume":"15","year":"2013","journal-title":"Israel Medical Association Journal"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1007\/BF01081524"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2307\/3576986"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-1773"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-113"},{"issue":"2","key":"27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2967\/jnumed.112.109330","volume":"54","year":"2013","journal-title":"Journal of Nuclear Medicine"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(02)00442-0"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1102526108"},{"issue":"1","key":"39","first-page":"177","volume":"40","year":"1999","journal-title":"Journal of Nuclear Medicine"},{"issue":"3","key":"40","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2967\/jnumed.110.079798","volume":"52","year":"2011","journal-title":"Journal of Nuclear Medicine"},{"issue":"4","key":"41","doi-asserted-by":"crossref","first-page":"517","DOI":"10.2967\/jnumed.107.048504","volume":"49","year":"2008","journal-title":"Journal of Nuclear Medicine"},{"issue":"7","key":"42","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.3109\/0284186X.2013.812800","volume":"52","year":"2013","journal-title":"Acta Oncologica"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/6\/1675"},{"issue":"3","key":"48","first-page":"237","volume":"3","year":"1980","journal-title":"Cancer Clinical Trials"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1118\/1.597506"},{"issue":"11","key":"50","first-page":"1851","volume":"45","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"issue":"1","key":"58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.radonc.2012.08.019","volume":"105","year":"2012","journal-title":"Radiotherapy & Oncology"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/103476"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.106.035774"},{"key":"65","first-page":"271","volume":"57","year":"2013","journal-title":"The Quarterly Journal of Nuclear Medicine and Molecular"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/624642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/624642.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2014\/624642.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T15:09:36Z","timestamp":1498144176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2014\/624642\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":65,"alternative-id":["624642","624642"],"URL":"https:\/\/doi.org\/10.1155\/2014\/624642","relation":{},"ISSN":["1748-670X","1748-6718"],"issn-type":[{"value":"1748-670X","type":"print"},{"value":"1748-6718","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}