{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:49:47Z","timestamp":1760042987950},"reference-count":4,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Dedifferentiation is defined as high-grade malignant tumor development out of a low-grade malignant tumor. We present an adenocarcinoma tumor of the parotid gland that was dedifferentiated from a low-grade epithelial-myoepithelial carcinoma and was followed up for 3 years. Our patient, a 46-year-old female, presented with a left parotid mass of 20-year duration. Histopathologic results showed that there was only one area of typical epithelial-myoepithelial carcinoma, with foci of poorly differentiated adenocarcinoma (not otherwise specified; NOS) and clear cytoplasm in the parotid gland. Immunohistochemical staining results showed SMA (+), P63 (+), CK8 (+), and S100 (+) on epithelial cells. A review of the literature revealed 22 previously reported cases of dedifferentiated epithelial-myoepithelial carcinoma. In these cases, the malignant tumors that dedifferentiated from epithelial-myoepithelial carcinoma were adenoid cystic carcinoma, actinic cell carcinoma, polymorphous low-grade adenocarcinoma, mucoepidermoid carcinoma, and intraductal carcinoma. In our case, the malignant tumor that dedifferentiated from the epithelial-myoepithelial carcinoma was a poorly differentiated adenocarcinoma. Histopathological results showed that metastases were not seen in the neck-dissection material. As a result, our case will make a contribution to the literature in terms of prognosis, because there are very few reported cases of dedifferentiated adenocarcinoma development arising from epithelial-myoepithelial carcinoma.<\/jats:p>","DOI":"10.1155\/2014\/629054","type":"journal-article","created":{"date-parts":[[2014,9,9]],"date-time":"2014-09-09T17:01:47Z","timestamp":1410282107000},"page":"1-3","source":"Crossref","is-referenced-by-count":7,"title":["Case Study of a Parotid Gland Adenocarcinoma Dedifferentiated from Epithelial-Myoepithelial Carcinoma"],"prefix":"10.1155","volume":"2014","author":[{"given":"Salih","family":"Ayd\u0131n","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umit","family":"Taskin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Ozdamar","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Y\u00fccebas","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Sar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Faruk","family":"Oktay","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dcmit Seza","family":"Tetikkurt","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ba\u011fc\u0131lar Education and Research Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181e366d2"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2011.12.012"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/325965"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1177\/1066896912468153"}],"container-title":["Case Reports in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2014\/629054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2014\/629054.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criot\/2014\/629054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T18:47:37Z","timestamp":1471546057000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criot\/2014\/629054\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":4,"alternative-id":["629054","629054"],"URL":"https:\/\/doi.org\/10.1155\/2014\/629054","relation":{},"ISSN":["2090-6765","2090-6773"],"issn-type":[{"value":"2090-6765","type":"print"},{"value":"2090-6773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}