{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:48:03Z","timestamp":1740167283654,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Obesity"],"published-print":{"date-parts":[[2014,1,12]]},"abstract":"<jats:p>Obesity paradox has been described in various populations of coronary artery disease, mainly asymptomatic subjects. However, relationship between obesity and coronary artery calcification detected by cardiac CT in symptomatic patients has rarely been demonstrated. This study seeks to investigate whether the paradoxical relationship between obesity and coronary artery calcification exists in patients with acute chest pain. A final cohort of 1030 chest pain patients presenting at our emergency department who underwent coronary evaluation by multidetector cardiac CT were examined. With absent-to-mild coronary calcification (CAC score &lt; 100) as a referent, multivariable analysis showed that presence of obesity (OR 0.564; 95% CI 0.395, 0.806; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math> 0.002), body mass index (OR 0.945; 95% CI 0.920, 0.971; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), body weight (OR 0.987; 95% CI 0.979, 0.995; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math> 0.001), and body surface area (OR 0.582; 95% CI 0.369, 0.920; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math> 0.020) were inversely associated with moderate-to-severe coronary calcification (CAC score \u2265 100). This study extends the concept of obesity paradox to symptomatic patients undergoing coronary artery calcium score assessment. However, biological explanation(s) of this paradox remains unanswered.<\/jats:p>","DOI":"10.1155\/2014\/634717","type":"journal-article","created":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T21:02:14Z","timestamp":1389560534000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Atherosclerosis Burden in Patients with Acute Chest Pain: Obesity Paradox"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7825-6493","authenticated-orcid":true,"given":"Kongkiat","family":"Chaikriangkrai","sequence":"first","affiliation":[{"name":"Department of Medicine, The Methodist Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahwash","family":"Kassi","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Methodist Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayf","family":"Khaleel bala","sequence":"additional","affiliation":[{"name":"Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Nabi","sequence":"additional","affiliation":[{"name":"Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2321-4063","authenticated-orcid":true,"given":"Su Min","family":"Chang","sequence":"additional","affiliation":[{"name":"Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX 77030, 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