{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:07:23Z","timestamp":1773079643841,"version":"3.50.1"},"reference-count":82,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Allergy"],"published-print":{"date-parts":[[2014,7,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This prospective, controlled, parallel-group observational study investigated the efficacy of a spray containing hyaluronic acid and dexpanthenol to optimise regular treatment after nasal cavity surgery in 49 patients with chronic rhinosinusitis.<jats:italic>Methods<\/jats:italic>. The control group received standard therapy. Mucosal regeneration was determined using rhinoscopy sum score (RSS). Pre- and postoperative nasal patency was tested using anterior rhinomanometry. The participants were questioned about their symptoms.<jats:italic>Results<\/jats:italic>. Regarding all RSS parameters (dryness, dried nasal mucus, fibrin deposition, and obstruction), mucosal regeneration achieved good final results in both groups, tending to a better improvement through the spray application, without statistically significant differences during the whole assessment period, the mean values being 7.04, 5.00, 3.66, and 3.00 (intervention group) and 7.09, 5.14, 4.36, and 3.33 (control group). No statistically significant benefit was identified for nasal breathing, foreign body sensation, and average rhinomanometric volume flow, which improved by 12.31% (control group) and 11.24% (nasal spray group).<jats:italic>Conclusion<\/jats:italic>. The investigational product may have additional benefit on postoperative mucosal regeneration compared to standard cleaning procedures alone. However, no statistically significant advantage could be observed in this observational study. Double-blind, controlled studies with larger populations will be necessary to evaluate the efficacy of this treatment modality.<\/jats:p>","DOI":"10.1155\/2014\/635490","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T08:55:01Z","timestamp":1404291301000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Efficacy of a Spray Containing Hyaluronic Acid and Dexpanthenol after Surgery in the Nasal Cavity (Septoplasty, Simple Ethmoid Sinus Surgery, and Turbinate Surgery)"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-6688","authenticated-orcid":true,"given":"Ina","family":"Gouteva","sequence":"first","affiliation":[{"name":"Institute of Medical Statistics, Informatics and Epidemiology, University Hospital of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9616-6942","authenticated-orcid":true,"given":"Kija","family":"Shah-Hosseini","sequence":"additional","affiliation":[{"name":"Institute of Medical Statistics, Informatics and Epidemiology, University Hospital of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-0056","authenticated-orcid":true,"given":"Peter","family":"Meiser","sequence":"additional","affiliation":[{"name":"Ursapharm Arzneimittel GmbH, Industriestra\u00dfe 35, 66129 Saarbr\u00fccken, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44548"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.2000.0244"},{"issue":"6","key":"3","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/10717540590952555","volume":"12","year":"2005","journal-title":"Drug Delivery"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10706"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997564"},{"key":"6","first-page":"111","volume":"39","year":"1991","journal-title":"HNO"},{"issue":"2","key":"7","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1046\/j.1524-475X.1999.00079.x","volume":"7","year":"1999","journal-title":"Wound Repair and Regeneration"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90317-7"},{"issue":"5","key":"9","first-page":"296","volume":"28","year":"1999","journal-title":"The Journal of Otolaryngology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.09.013"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/S0945-053X(01)00184-6"},{"key":"12","first-page":"683","volume":"61","year":"2007","journal-title":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej"},{"issue":"2","key":"13","first-page":"129","volume":"54","year":"2012","journal-title":"Panminerva Medica"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.07.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1089\/jop.1994.10.83"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000248794.63898.0f"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1220647"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02057.x"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S30794"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000248858.26595.46"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.104667"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00391.x"},{"issue":"5","key":"23","first-page":"513","volume":"15","year":"1998","journal-title":"Critical Reviews in Therapeutic Drug Carrier Systems"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015894910416"},{"issue":"3","key":"25","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1023\/B:PHAR.0000026823.82950.ff","volume":"26","year":"2004","journal-title":"Pharmacy World and Science"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.07.009"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2010.02.002"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5173(03)00259-X"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00285-0"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0410-2"},{"issue":"1-2","key":"31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-3659(99)00228-X","volume":"65","year":"2000","journal-title":"Journal of Controlled Release"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.10.009"},{"issue":"2","key":"33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/(SICI)1097-4636(199811)42:2<172::AID-JBM2>3.0.CO;2-M","volume":"42","year":"1998","journal-title":"Journal of Biomedical Materials Research"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.05.054"},{"issue":"4","key":"35","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2174\/138920108785161596","volume":"9","year":"2008","journal-title":"Current Pharmaceutical Biotechnology"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7322"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20100920-02"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.70"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.83.10.1121"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700169"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.8.879"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0841-3"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3283346f36"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-42685"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1159\/000276877"},{"issue":"3","key":"46","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0015-0282(97)80085-4","volume":"67","year":"1997","journal-title":"Fertility and Sterility"},{"issue":"1","key":"47","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0015-0282(97)81472-0","volume":"68","year":"1997","journal-title":"Fertility and Sterility"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00573-6"},{"issue":"5","key":"49","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S0015-0282(16)58642-7","volume":"66","year":"1996","journal-title":"Fertility and Sterility"},{"key":"50","first-page":"191","volume":"381","year":"1993","journal-title":"Progress in Clinical and Biological Research"},{"issue":"4","key":"51","first-page":"297","volume":"183","year":"1996","journal-title":"Journal of the American College of Surgeons"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.05.081"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1136\/ard.55.7.424"},{"issue":"6","key":"54","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1742-1241.2003.tb10535.x","volume":"57","year":"2003","journal-title":"International Journal of Clinical Practice"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.11.1240"},{"issue":"7","key":"56","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.2106\/00004623-200307000-00003","volume":"85","year":"2003","journal-title":"The Journal of Bone and Joint Surgery A"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203060-00005"},{"issue":"7","key":"58","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00106-003-0961-4","volume":"52","year":"2004","journal-title":"HNO"},{"issue":"1","key":"59","first-page":"58","volume":"95","year":"2012","journal-title":"Journal of the Medical Association of Thailand"},{"issue":"2","key":"60","first-page":"114","volume":"76","year":"2001","journal-title":"H & G"},{"key":"61","year":"1995"},{"issue":"7","key":"62","first-page":"659","volume":"50","year":"2000","journal-title":"Arzneimittel-Forschung"},{"issue":"3","key":"63","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-2003-38406","volume":"82","year":"2003","journal-title":"Laryngo-Rhino-Otologie"},{"key":"64","first-page":"432","volume":"43","year":"1992","journal-title":"Der Hautarzt"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997014"},{"key":"66","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-295"},{"key":"68","first-page":"48","volume":"39","year":"1991","journal-title":"HNO"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38941"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36133"},{"key":"72","year":"2011"},{"issue":"6","key":"73","first-page":"253","volume":"25","year":"1999","journal-title":"Drugs under Experimental and Clinical Research"},{"issue":"4","key":"74","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/194589240301700405","volume":"17","year":"2003","journal-title":"American Journal of Rhinology"},{"key":"75","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.3035"},{"issue":"3","key":"76","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/194589240301700304","volume":"17","year":"2003","journal-title":"American Journal of Rhinology"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3176"},{"issue":"4","key":"78","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000101539","volume":"69","year":"2007","journal-title":"ORL"},{"issue":"10","key":"79","first-page":"1558","volume":"91","year":"2008","journal-title":"Journal of the Medical Association of Thailand"},{"key":"80","year":"2013"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-997637"},{"issue":"7","key":"82","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/BF01463560","volume":"248","year":"1991","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"1","key":"83","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/039463201302600113","volume":"26","year":"2013","journal-title":"International Journal of Immunopathology and Pharmacology"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-009-1938-8"}],"container-title":["Journal of Allergy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/635490.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/635490.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/archive\/2014\/635490.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T22:54:49Z","timestamp":1689375289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ja\/2014\/635490\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":82,"alternative-id":["635490","635490"],"URL":"https:\/\/doi.org\/10.1155\/2014\/635490","relation":{},"ISSN":["1687-9783","1687-9791"],"issn-type":[{"value":"1687-9783","type":"print"},{"value":"1687-9791","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}