{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:48:03Z","timestamp":1788263283662,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"crossref","award":["LIG-09\/2012"],"award-info":[{"award-number":["LIG-09\/2012"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Latvian National Research Programme","award":["LIG-09\/2012"],"award-info":[{"award-number":["LIG-09\/2012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>A series of modified saccharin sulfonamides have been designed as carbonic anhydrase (CA) inhibitors and synthesized. Their binding to CA isoforms I, II, VII, XII, and XIII was measured by the fluorescent thermal shift assay (FTSA) and isothermal titration calorimetry (ITC). Saccharin bound the CAs weakly, exhibiting the affinities of 1\u201310\u2009mM for four CAs except CA I where binding could not be detected. Several sulfonamide-bearing saccharines exhibited strong affinities of 1\u201310\u2009nM towards particular CA isoforms. The functional group binding Gibbs free energy additivity maps are presented which may provide insights into the design of compounds with increased affinity towards selected CAs.<\/jats:p>","DOI":"10.1155\/2014\/638902","type":"journal-article","created":{"date-parts":[[2014,9,3]],"date-time":"2014-09-03T19:56:04Z","timestamp":1409774164000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII"],"prefix":"10.1155","volume":"2014","author":[{"given":"Vaida","family":"Mork\u016bnait\u0117","sequence":"first","affiliation":[{"name":"Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius University, Grai\u010di\u016bno 8, LT-02241 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Baranauskien\u0117","sequence":"additional","affiliation":[{"name":"Department of Biothermodynamics and Drug Design, Institute of 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