{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:38:52Z","timestamp":1740173932136,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,8,3]],"date-time":"2014-08-03T00:00:00Z","timestamp":1407024000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2014,8,3]]},"abstract":"Aims<\/jats:italic>. Efficacy and safety of DPP-4 inhibitor, sitagliptin, add-on therapy to insulin were investigated in Japanese patients with type 2 diabetes. Subjects and Methods<\/jats:italic>. Two hundred and sixteen patients (126 men, 65 \u00b1 12 years old, BMI 24.9 \u00b1 4.5, means \u00b1 S.D.) who had been treated by insulin alone or insulin combined with other oral hypoglycemic agents (OHAs) were recruited, and sitagliptin was added for 3 months. Results<\/jats:italic>. HbA1c was significantly decreased after 3 months of add-on therapy as a whole (8.56 \u00b1 1.50% to 7.88 \u00b1 1.25%, P<\/mml:mi><<\/mml:mo>0.0001<\/mml:mn><\/mml:math>). Body weight did not change and insulin dosage was significantly (P<\/mml:mi><<\/mml:mo>0.0001<\/mml:mn><\/mml:math>) decreased for 3 months. Furthermore, day-to-day glucose variability was significantly reduced (18.3 \u00b1 9.1 to 16.1 \u00b1 8.1%, P<\/mml:mi><<\/mml:mo>0.05<\/mml:mn><\/mml:math>). In stepwise multiple regression analysis on \u0394HbA1c as an outcome variable, the higher baseline HbA1c value and a preserved CPR were selected as significant predictive variables. Fifteen patients complained of mild hypoglycemia without any assistance during 3 months of sitagliptin add-on, while no severe hypoglycemic episode was reported. Conclusions<\/jats:italic>. Add-on of sitagliptin to ongoing insulin therapy effectively reduced either HbA1c level or glucose fluctuation and could be a practical and well-tolerated alternative to treat Japanese patients with type 2 diabetes who had been inadequately controlled by insulin with or without other OHAs.<\/jats:p>","DOI":"10.1155\/2014\/639489","type":"journal-article","created":{"date-parts":[[2014,8,3]],"date-time":"2014-08-03T21:02:47Z","timestamp":1407099767000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Adding of Sitagliptin on Insulin Therapy Effectively and Safely Reduces a Hemoglobin A1c Level and Glucose Fluctuation in Japanese Patients with Type 2 Diabetes"],"prefix":"10.1155","volume":"2014","author":[{"given":"Yuji","family":"Tajiri","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiko","family":"Kawano","sequence":"additional","affiliation":[{"name":"Municipal Yame General Hospital, Yame 834-0034, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Hirao","sequence":"additional","affiliation":[{"name":"Municipal Yame General Hospital, Yame 834-0034, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamami","family":"Oshige","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinpei","family":"Iwata","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Ono","sequence":"additional","affiliation":[{"name":"Kouhoukai Takagi Hospital, Okawa 831-0016, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizuko","family":"Inada","sequence":"additional","affiliation":[{"name":"Inada Clinic, Kurume 830-0039, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Akashi","sequence":"additional","affiliation":[{"name":"Shimada Hospital, Ogori 838-0141, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Tenjinkai Koga Hospital 21, Kurume 839-0801, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1472-3758","authenticated-orcid":true,"given":"Yuichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Saint Mary Hospital, Kurume 830-8543, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Tojikubo","sequence":"additional","affiliation":[{"name":"Tenjinkai Shin-Koga Hospital, Kurume 830-8577, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-Machi, Kurume 830-0011, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2337\/dc05-1365","volume":"29","year":"2006","journal-title":"Diabetes 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