{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:03:05Z","timestamp":1740164585000,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Cutaneous Hodgkin lymphoma is a rare condition. Specific neoplastic involvement can be primary (confined to the skin) or secondary to systemic involvement (metastatic). Cutaneous involvement by HL usually occurs late in the course and is associated with poor prognosis; however in some cases it can exhibit indolent behavior. Skin involvement with nonspecific cutaneous findings may represent a paraneoplastic syndrome. We describe a case of 46-year-old white male patient presented with rash and lymphadenopathy which led to the diagnosis of stage IVE mixed cellularity classical Hodgkin lymphoma with skin involvement. His disease was refractory to multiple lines of chemotherapy including (1) AVD (doxorubicin\/bleomycin\/dacarbazine), (2) brentuximab, and (3) bendamustine, he later achieved complete remission with (4) GCD (gemcitabine\/carboplatin\/dexamethasone) salvage regimen. Bleomycin was not given secondary to poor pulmonary function tests. His treatment was complicated after AVD with multiple pneumothoraces which unmasked the diagnosis of ZZ phenotype alpha-1 antitrypsin (ATT) deficiency. Simultaneous existence of Hodgkin lymphoma and ATT is rarely reported.<\/jats:p>","DOI":"10.1155\/2014\/642868","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T17:19:14Z","timestamp":1400001554000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6627-1933","authenticated-orcid":true,"given":"Mohamad","family":"Khawandanah","sequence":"first","affiliation":[{"name":"Hematology-Oncology Section, Department of Medicine, Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, 800 NE 10th Street, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Kraus","sequence":"additional","affiliation":[{"name":"Department of Pathology, The University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, BMSB 451, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Cherry","sequence":"additional","affiliation":[{"name":"Hematology-Oncology Section, Department of Medicine, Stephenson Cancer Center, The University of Oklahoma Health Sciences Center, 800 NE 10th Street, Oklahoma City, OK 73104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20006"},{"volume-title":"Hodgkin lymphoma","year":"2008","key":"2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181a753cc"},{"key":"4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/00000478-199606000-00014","volume":"20","year":"1996","journal-title":"The American Journal of Surgical Pathology"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.11.1055"},{"issue":"5","key":"6","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/1097-0142(19850301)55:5<1136::AID-CNCR2820550532>3.0.CO;2-T","volume":"55","year":"1985","journal-title":"Cancer"},{"key":"7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3109\/15412555.2013.763782","volume":"10","year":"2013","journal-title":"Chronic Obstructive Pulmonary Disease"},{"key":"8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3109\/15412555.2013.764403","volume":"10","year":"2013","journal-title":"Chronic Obstructive Pulmonary Disease"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/1097-0142(197507)36:1<252::AID-CNCR2820360128>3.0.CO;2-7","volume":"36","year":"1975","journal-title":"Cancer"},{"key":"12","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1200\/JCO.2011.38.0410","volume":"30","year":"2012","journal-title":"Journal of Clinical Oncology"},{"key":"13","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1200\/JCO.2012.45.3308","volume":"31","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.491137"},{"key":"22","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/rccm.168.7.818","volume":"168","year":"2003","journal-title":"The American Journal of Respiratory and Critical Care Medicine"},{"issue":"11","key":"10","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/jcp.35.11.1213","volume":"35","year":"1982","journal-title":"Journal of Clinical Pathology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.10.1097"},{"key":"24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1378\/chest.128.1.445","volume":"128","year":"2005","journal-title":"Chest"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01414-7"},{"volume":"219","year":"1959","key":"15"},{"issue":"3","key":"16","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/1097-0142(197809)42:3<1219::AID-CNCR2820420328>3.0.CO;2-3","volume":"42","year":"1978","journal-title":"Cancer"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1995.tb00743.x"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/1097-0142(19800115)45:2<354::AID-CNCR2820450227>3.0.CO;2-#","volume":"45","year":"1980","journal-title":"Cancer"},{"issue":"1","key":"19","first-page":"115","volume":"17","year":"1976","journal-title":"Cutis"},{"key":"20","first-page":"2373","volume-title":"Cutaneous lymphomas and lymphocytic infiltrates","volume":"3","year":"1998"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572009005000085"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2014\/642868.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2014\/642868.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2014\/642868.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T09:08:52Z","timestamp":1498122532000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crihem\/2014\/642868\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":24,"alternative-id":["642868","642868"],"URL":"https:\/\/doi.org\/10.1155\/2014\/642868","relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2014]]}}}