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Although we previously demonstrated that propolis has antidepressant\u2010like activity, the effect of CAPE on this activity remains unknown. The present study assessed whether treatment with CAPE (5, 10, and 20\u2009<jats:italic>\u00b5<\/jats:italic>mol\/kg for 21 days) has an antidepressant\u2010like effect in mice subjected to chronic unpredictable stress via tail suspension (TST) and forced swim (FST) tests. CAPE administration induced behaviors consistent with an antidepressant effect, evidenced by decreased immobility in the TST and FST independent of any effect on serum corticosterone secretion. Western blots, conducted subsequent to behavioral assessment, revealed that CAPE significantly decreased glucocorticoid receptor phosphorylation at S234 (pGR(S234)), resulting in an increased pGR(S220\/S234) ratio. We also observed negative correlations between pGR(S220)\/(S234) and p38 mitogen\u2010activated protein kinase (p38MAPK) phosphorylation, which was decreased by CAPE treatment. These findings suggest that CAPE treatment exerts an antidepressant\u2010like effect via downregulation of p38MAPK phosphorylation, thereby contributing to enhanced GR function.<\/jats:p>","DOI":"10.1155\/2014\/646039","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T21:04:04Z","timestamp":1416171844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Novel Antidepressant\u2010Like Activity of Caffeic Acid Phenethyl Ester Is Mediated by Enhanced Glucocorticoid Receptor Function in the Hippocampus"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mi-Sook","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Han","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-ram","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hae","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Jin","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwan-Su","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Seon","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoji","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hyun","family":"Hahm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insop","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Her","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,16]]},"reference":[{"key":"e_1_2_8_1_2","first-page":"741","article-title":"Limbic-hypothalamic-pituitary-adrenal axis in depression (literature review)","volume":"30","author":"Twardowska K.","year":"1996","journal-title":"Psychiatria Polska"},{"key":"e_1_2_8_2_2","first-page":"415","article-title":"Serotoninergic system and limbic-hypothalamic-pituitary-adrenal axis (LHPA axis) in depression","volume":"40","author":"Cuba\u0142a W. 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