{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:20:23Z","timestamp":1760217623036},"reference-count":33,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Spanish Society of Nephrology and ACINEF"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this prospective, nonrandomised, open-label, proof-of-concept study, we evaluated the hypothesis that selective vitamin D receptor activation with paricalcitol is an effective target to modulate inflammation in CKD patients. Eight patients with an estimated glomerular filtration rate between 15 and 44\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>and an intact parathyroid hormone (PTH) level higher than 110\u2009pg\/mL received oral paricalcitol (1\u2009<jats:italic>\u03bc<\/jats:italic>g\/48 hours) as therapy for secondary hyperparathyroidism. Nine patients matched by age, sex, and stage of CKD, but a PTH level &lt;110\u2009pg\/mL, were enrolled as a control group. Our results show that five months of paricalcitol administration were associated with a reduction in serum concentrations of hs-CRP (13.9%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), TNF-<jats:italic>\u03b1<\/jats:italic>(11.9%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), and IL-6 (7%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), with a nonsignificant increase of IL-10 by 16%. In addition, mRNA expression levels of the TNF<jats:italic>\u03b1<\/jats:italic>and IL-6 genes in peripheral blood mononuclear cells decreased significantly by 30.8% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>) and 35.4% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:math>), respectively. In conclusion, selective VDR activation is an effective target to modulate inflammation in CKD.<\/jats:p>","DOI":"10.1155\/2014\/670475","type":"journal-article","created":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T10:58:32Z","timestamp":1389265112000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["Selective Vitamin D Receptor Activation as Anti-Inflammatory Target in Chronic Kidney Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"J.","family":"Donate-Correa","sequence":"first","affiliation":[{"name":"Research Unit, University Hospital Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"},{"name":"GEENDIAB (Grupo Espa\u00f1ol para el Estudio de la Nefropat\u00eda Diab\u00e9tica) and REDINREN (RD12\/0021\/0019), Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Dom\u00ednguez-Pimentel","sequence":"additional","affiliation":[{"name":"Nephrology Service, University Hospital Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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