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These rare bone disorders also represent a therapeutic challenge for clinicians, due to lack of understanding of underlying mechanisms. This systematic review explored current literature on therapeutic directions for the following rare genetic bone disorders: fibrous dysplasia, Gorham-Stout syndrome, fibrodysplasia ossificans progressiva, melorheostosis, multiple hereditary exostosis, osteogenesis imperfecta, craniometaphyseal dysplasia, achondroplasia, and hypophosphatasia. The disease mechanisms of Gorham-Stout disease, melorheostosis, and multiple hereditary exostosis are not fully elucidated. Inhibitors of the ACVR1\/ALK2 pathway may serve as possible therapeutic intervention for FOP. The use of bisphosphonates and IL-6 inhibitors has been explored to be useful in the treatment of fibrous dysplasia, but more research is warranted. Cell therapy, bisphosphonate polytherapy, and human growth hormone may avert the pathology in osteogenesis imperfecta, but further studies are needed. There are still no current effective treatments for these bone disorders; however, significant promising advances in therapeutic modalities were developed that will limit patient suffering and treat their skeletal disabilities.<\/jats:p>","DOI":"10.1155\/2014\/670842","type":"journal-article","created":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T21:05:39Z","timestamp":1414011939000},"page":"1-16","source":"Crossref","is-referenced-by-count":32,"title":["Molecular, Phenotypic Aspects and Therapeutic Horizons of Rare Genetic Bone Disorders"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-2786","authenticated-orcid":true,"given":"Taha","family":"Faruqi","sequence":"first","affiliation":[{"name":"Nova Southeastern University Health Sciences Division, Fort-Lauderdale-Davie, FL 33314, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Nova 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