{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:56:41Z","timestamp":1717808201795},"reference-count":44,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Medicinal Chemistry"],"published-print":{"date-parts":[[2014,9,10]]},"abstract":"<jats:p>An efficient one pot condensation of naphthols (1), 2,5-disubstituted indole-3-carboxaldehydes (2), and secondary amines (3) has been achieved using dichloromethane as a solvent, stirring at room temperature. Some of the new [(disubstituted amino)(5-substituted 2-phenyl-1<jats:italic>H<\/jats:italic>-indol-3-yl)methyl]naphthalene-ols (4) derivatives were prepared in good yields. The significant features of this method are simple work-up procedure, inexpensive nontoxic solvent, shorter reaction times, and excellent product yields. The structures of newly synthesized compounds (<jats:bold>4a\u2013r<\/jats:bold>) are confirmed by their elemental analysis, FTIR, <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C NMR, and mass spectral data. These compounds were screened for their <jats:italic>in vitro<\/jats:italic> antioxidant, antimicrobial, antitubercular, and anticancer activities. Among the synthesized compounds (<jats:bold>4a\u2013r<\/jats:bold>), the compound <jats:bold>4e<\/jats:bold> exhibited highest activity for radical scavenging and ferric ions reducing antioxidant power activities; compounds <jats:bold>4b<\/jats:bold>, <jats:bold>4h<\/jats:bold>, and <jats:bold>4k<\/jats:bold> showed good metal chelating activity. Compounds <jats:bold>4n<\/jats:bold> and <jats:bold>4q<\/jats:bold> showed excellent antimicrobial activities with MIC value 08\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL against tested strains. Compounds <jats:bold>4h<\/jats:bold>, <jats:bold>4k<\/jats:bold>, <jats:bold>4n<\/jats:bold>, and <jats:bold>4q<\/jats:bold> exhibited promising antitubercular activity with MIC value 12.5\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL. Compounds <jats:bold>4k<\/jats:bold> and <jats:bold>4q<\/jats:bold> exhibited 100% cell lysis at concentration 10\u2009<jats:italic>\u00b5<\/jats:italic>g\/mL against MDA-MB-231 (human adenocarcinoma mammary gland) cell lines.<\/jats:p>","DOI":"10.1155\/2014\/673206","type":"journal-article","created":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T21:00:56Z","timestamp":1410382856000},"page":"1-12","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis and Biological Evaluation of Aminonaphthols Incorporated Indole Derivatives"],"prefix":"10.1155","volume":"2014","author":[{"given":"Saundane","family":"Anand Raghunath","sequence":"first","affiliation":[{"name":"Department of Post-Graduate Studies and Research in Chemistry, Gulbarga University, Gulbarga, Karnataka 585 106, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirankumar","family":"Nandibeoor Mathada","sequence":"additional","affiliation":[{"name":"Department of Post-Graduate Studies and 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