{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:50:20Z","timestamp":1768686620051,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"National Science Council of China","award":["NSC97-2321-B-384-001-MY2"],"award-info":[{"award-number":["NSC97-2321-B-384-001-MY2"]}]},{"name":"National Science Council of China","award":["NSC99-2314-B-384-005-MY3"],"award-info":[{"award-number":["NSC99-2314-B-384-005-MY3"]}]},{"name":"National Science Council of China","award":["NSC97-2321-B-384-001-MY2"],"award-info":[{"award-number":["NSC97-2321-B-384-001-MY2"]}]},{"name":"National Science Council of China","award":["NSC99-2314-B-384-005-MY3"],"award-info":[{"award-number":["NSC99-2314-B-384-005-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Heatstroke is characterized by excessive hyperthermia associated with systemic inflammatory responses, which leads to multiple organ failure, in which brain disorders predominate. This definition can be almost fulfilled by a mouse model of heatstroke used in the present study. Unanesthetized mice were exposed to whole body heating (41.2\u00b0C for 1 hour) and then returned to room temperature (26\u00b0C) for recovery. Immediately after termination of whole body heating, heated mice displayed excessive hyperthermia (body core temperature ~42.5\u00b0C). Four hours after termination of heat stress, heated mice displayed (i) systemic inflammation; (ii) ischemic, hypoxic, and oxidative damage to the hypothalamus; (iii) hypothalamo-pituitary-adrenocortical axis impairment (reflected by plasma levels of both adrenocorticotrophic-hormone and corticosterone); (iv) decreased fractional survival; and (v) thermoregulatory deficits (e.g., they became hypothermia when they were exposed to room temperature). These heatstroke reactions can be significantly attenuated by human umbilical cord blood-derived CD34<jats:sup>+<\/jats:sup>cells therapy. Our data suggest that human umbilical cord blood-derived stem cells therapy may improve outcomes of heatstroke in mice by reducing systemic inflammation as well as hypothalamo-pituitary-adrenocortical axis impairment.<\/jats:p>","DOI":"10.1155\/2014\/685683","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T19:11:05Z","timestamp":1396897865000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Umbilical Cord Blood-Derived Stem Cells Improve Heat Tolerance and Hypothalamic Damage in Heat Stressed Mice"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ling-Shu","family":"Tseng","sequence":"first","affiliation":[{"name":"School of Dentistry, Kaohsiung Medical University, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Hsien","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan City 710, Taiwan"},{"name":"Da-An Women and Children Hospital, Tainan City 710, Taiwan"},{"name":"Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan City 710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao-Tsun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan City 710, Taiwan"},{"name":"Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan City 710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2499-8632","authenticated-orcid":true,"given":"Ying-Chu","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Dentistry, Kaohsiung Medical University, Kaohsiung City 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4565(99)00069-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.10.023"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb51748.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030263"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00675.2005"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00030-0"},{"issue":"6","key":"7","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/0031-9384(89)90097-8","volume":"45","year":"1989","journal-title":"Physiology & Behavior"},{"issue":"1","key":"8","first-page":"67","volume":"52","year":"2003","journal-title":"Physiological Research"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.04.035"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2002.00276.x"},{"issue":"11","key":"11","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","year":"2001","journal-title":"Stroke"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000165966.28936.89"},{"issue":"3","key":"13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3727\/096020198389924","volume":"11","year":"2002","journal-title":"Cell Transplantation"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1089\/152581603322023007"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(09)60065-6"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2006.04.003"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000180983.55623.2b"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2174\/1570159X11311020001","volume":"11","year":"2013","journal-title":"Current Neuropharmacology"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-111"},{"issue":"5","key":"20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1002\/ana.410110510","volume":"11","year":"1982","journal-title":"Annals of Neurology"},{"key":"21","year":"1986"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(97)00918-X"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000150779.47107.d5"},{"issue":"3","key":"24","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","volume":"27","year":"1969","journal-title":"Analytical Biochemistry"},{"issue":"1","key":"25","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0003-2697(80)90139-6","volume":"106","year":"1980","journal-title":"Analytical Biochemistry"},{"issue":"26","key":"26","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2174\/092986706778742945","volume":"13","year":"2006","journal-title":"Current Medicinal Chemistry"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2006.11.003"},{"key":"28","first-page":"333","volume":"527, part 2","year":"2000","journal-title":"The Journal of Physiology"},{"issue":"1","key":"29","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2143\/AC.57.1.2005374","volume":"57","year":"2002","journal-title":"Acta Cardiologica"},{"issue":"4","key":"30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archsurg.1989.01410040055012","volume":"124","year":"1989","journal-title":"Archives of Surgery"},{"key":"31","doi-asserted-by":"crossref","first-page":"N3","DOI":"10.1097\/00003246-200004001-00002","volume":"28","year":"2000","journal-title":"Critical Care Medicine"},{"issue":"4, part 2","key":"32","first-page":"H2072","volume":"273","year":"1997","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000248593.71388.40"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.19.1.683"},{"key":"35","first-page":"367","volume":"388","year":"1994","journal-title":"Progress in clinical and biological research"},{"issue":"25","key":"36","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1056\/NEJMra011089","volume":"346","year":"2002","journal-title":"The New England Journal of Medicine"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/685683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/685683.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/685683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T05:18:36Z","timestamp":1565327916000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/685683\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":36,"alternative-id":["685683","685683"],"URL":"https:\/\/doi.org\/10.1155\/2014\/685683","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}