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An ischemic stroke was induced in rats by a selective occlusion of the middle cerebral artery (MCA) with whole blood clots and then orally treated with<jats:italic>A. camphorata<\/jats:italic>(0.25 and 0.75\u2009g\/kg\/day) alone and combined with aspirin (5\u2009mg\/kg\/day). Sixty days later, the brains were removed, sectioned, and stained with triphenyltetrazolium chloride and analysed by a commercial image processing software program. Brain infarct volume, neurobehavioral score, cerebral blood perfusion, and subarachnoid and intracerebral hemorrhage incidence were perceived. In addition, potential bleeding side effect of the combinative therapy was assessed by measuring hemoglobin (Hb) content during intracerebral hemorrhage and gastric bleeding, prothrombin time (PT), and occlusion time (OT) after oral administration. Posttreatment with high dose<jats:italic>A. camphorata<\/jats:italic>significantly reduced infarct volume and improved neurobehavioral score (<jats:italic>P<\/jats:italic>&lt; 0.05). Since<jats:italic>A. camphorata<\/jats:italic>alone or with aspirin did not alter the Hb level, this treatment is safe and does not cause hemorrhagic incident. Remarkably, the combination of<jats:italic>A. camphorata<\/jats:italic>and aspirin did not show a significant effect on the bleeding time, PT and OT increase suggesting that<jats:italic>A. camphorata<\/jats:italic>may have the neuroprotective effect without the prolongation of bleeding time or coagulation time. From these observations, we suggest that combinative therapy of<jats:italic>A. camphorata<\/jats:italic>and aspirin might offer enhanced neuroprotective efficacies without increasing side effects.<\/jats:p>","DOI":"10.1155\/2014\/686109","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T17:12:26Z","timestamp":1405962746000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Extract of<i>Antrodia camphorata<\/i>Exerts Neuroprotection against Embolic Stroke in Rats without Causing the Risk of Hemorrhagic Incidence"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ye-Ming","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Surgery, Hsinchu Mackay Memorial Hospital, Hsinchu 300, Taiwan"},{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College, Taipei 112, Taiwan"},{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiu-Yun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Lin","family":"Yen","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pitchairaj","family":"Geraldine","sequence":"additional","affiliation":[{"name":"Department of Animal Science, School of Life Sciences, Tiruchirappalli, Tamil Nadu 620 024, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Chou","family":"Lan","sequence":"additional","affiliation":[{"name":"Sheen Chain Biotechnology, Co., Ltd., Taipei 115, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joen-Rong","family":"Sheu","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Jen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nursing, Mackay Medicine, Nursing and Management College, Taipei 112, Taiwan"},{"name":"Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan"},{"name":"Mackay Junior College of Medicine, Nursing, and Management, Mackay Memorial Hospital, Taipei 112, Taiwan"},{"name":"Department of Surgery, Mackay Memorial Hospital, No. 92, Section 2, Zhongshan N. 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