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Transected rat sciatic nerve stumps were inserted into a nine mm long silicone tube, which contained four, five mm long, smaller tubes, thus leaving a five mm gap for regenerating nerve fibers. Six weeks later, several new nerve structures were formed not only in the four smaller tubes, but also in the spaces in-between. The 7\u20139 new continuous nerve structures, which were isolated as individual free nerves after removal of the tubes, were delineated by a perineurium and contained both myelinated and unmyelinated nerve fibers as well as blood vessels. Stimulation of the proximal nerve elicited contractions in distal muscles. Thin metal electrodes, inserted initially into the smaller tubes in some experiments, became embedded in the new nerve structures and when stimulated contractions of the distal muscles were observed. The \u201ctubes within a tube\u201d technique, creating multiple new nerves from a single \u201cmother\u201d nerve, can be used to record multiple signals for prosthetic device control or as sources for supply of multiple denervated targets.<\/jats:p>","DOI":"10.1155\/2014\/689127","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T01:27:06Z","timestamp":1397784426000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["The Multiple Silicone Tube Device, \u201cTubes within a Tube,\u201d for Multiplication in Nerve Reconstruction"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-8822","authenticated-orcid":true,"given":"Fredrik","family":"Johansson","sequence":"first","affiliation":[{"name":"Department of Biology\/Functional Zoology, Lund University, S\u00f6lvegatan 35, 223 62 Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars 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