{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:51:22Z","timestamp":1777517482735,"version":"3.51.4"},"reference-count":9,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>Ectopic pregnancy (EP) is a significant cause of morbidity and mortality during the first trimester of pregnancy. Small unruptured tubal pregnancies can be treated medically with a single dose of methotrexate (MTX).<jats:italic>Objective.<\/jats:italic>The aim of this study was to evaluate the stability of a 25\u2009mg\/mL solution of MTX to devise a secure delivery circuit for the preparation and use of this medication in the management of EP.<jats:italic>Method.<\/jats:italic>MTX solutions were packaged in polypropylene syringes, stored over an 84-day period, and protected from light either at +2 to +8\u00b0C or at 23\u00b0C. We assessed the physical and chemical stability of the solutions at various time points over the storage period. A pharmaceutical delivery circuit was implemented that involved the batch preparation of MTX syringes.<jats:italic>Results.<\/jats:italic>We show that 25\u2009mg\/mL MTX solutions remain stable over an 84-day period under the storage conditions tested. Standard doses were prepared, ranging from 50\u2009mg to 100\u2009mg. The results of this study suggest that MTX syringes can be prepared in advance by the pharmacy, ready to be dispensed at any time that a diagnosis of EP is made.<jats:italic>Conclusion.<\/jats:italic>The high stability of a 25\u2009mg\/mL MTX solution in polypropylene syringes makes it possible to implement a flexible and cost-effective delivery circuit for ready-to-use preparations of this drug, providing 24-hour access and preventing treatment delays.<\/jats:p>","DOI":"10.1155\/2014\/689308","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T21:05:26Z","timestamp":1399928726000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["Implementation Study of Patient-Ready Syringes Containing 25\u2009mg\/mL Methotrexate Solution for Use in Treating Ectopic Pregnancy"],"prefix":"10.1155","volume":"2014","author":[{"given":"R.","family":"Respaud","sequence":"first","affiliation":[{"name":"EA 6306, IMT, Laboratoire de Chimie Organique, Facult\u00e9 de Pharmacie, Universit\u00e9 de Tours, 31 Avenue Monge, 37200 Tours, France"},{"name":"Pharmacie, CHRU de Tours, 2 Boulevard Tonnell\u00e9, 37044 Tours Cedex 9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Gaudy","sequence":"additional","affiliation":[{"name":"Pharmacie, CHRU de Tours, 2 Boulevard Tonnell\u00e9, 37044 Tours Cedex 9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Arlicot","sequence":"additional","affiliation":[{"name":"P\u00f4le de Gyn\u00e9cologie Obst\u00e9trique, M\u00e9decine Foetale M\u00e9decine et Biologie de la Reproduction, Centre Olympe-de-Gouges, CHRU de Tours, 2, Boulevard Tonnell\u00e9, 37044 Tours Cedex 9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Tournamille","sequence":"additional","affiliation":[{"name":"EA 6306, IMT, Laboratoire de Chimie Organique, Facult\u00e9 de Pharmacie, Universit\u00e9 de Tours, 31 Avenue Monge, 37200 Tours, France"},{"name":"Pharmacie, CHRU de Tours, 2 Boulevard Tonnell\u00e9, 37044 Tours Cedex 9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Viaud-Massuard","sequence":"additional","affiliation":[{"name":"EA 6306, IMT, Laboratoire de Chimie Organique, Facult\u00e9 de Pharmacie, Universit\u00e9 de Tours, 31 Avenue Monge, 37200 Tours, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Elfakir","sequence":"additional","affiliation":[{"name":"Institut de Chimie Organique et Analytique (ICOA) UMR CNRS 7311, Universit\u00e9 d\u2019Orl\u00e9ans, BP 6759, 45067 Orl\u00e9ans Cedex 2, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Antier","sequence":"additional","affiliation":[{"name":"Pharmacie, CHRU de Tours, 2 Boulevard Tonnell\u00e9, 37044 Tours Cedex 9, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67103-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det037"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/637094"},{"issue":"6","key":"4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0015-0282(16)46349-1","volume":"37","year":"1982","journal-title":"Fertility and Sterility"},{"key":"5","doi-asserted-by":"publisher","DOI":"10. 5001\/omj.2011.24"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharma.2011.07.002"},{"issue":"10","key":"7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/qjmed\/92.10.551","volume":"92","year":"1999","journal-title":"QJM"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.08.031"},{"issue":"1","key":"10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0897-1897(95)80279-7","volume":"8","year":"1995","journal-title":"Applied Nursing Research"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/689308.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/689308.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/689308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T13:05:06Z","timestamp":1498136706000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/689308\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":9,"alternative-id":["689308","689308"],"URL":"https:\/\/doi.org\/10.1155\/2014\/689308","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}