{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:13:46Z","timestamp":1790802826866,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003828","name":"Hungkuang University","doi-asserted-by":"publisher","award":["HK97-031"],"award-info":[{"award-number":["HK97-031"]}],"id":[{"id":"10.13039\/501100003828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003828","name":"Hungkuang University","doi-asserted-by":"publisher","award":["HK 98-039"],"award-info":[{"award-number":["HK 98-039"]}],"id":[{"id":"10.13039\/501100003828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003828","name":"Hungkuang University","doi-asserted-by":"publisher","award":["HK97-031"],"award-info":[{"award-number":["HK97-031"]}],"id":[{"id":"10.13039\/501100003828","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003828","name":"Hungkuang University","doi-asserted-by":"publisher","award":["HK 98-039"],"award-info":[{"award-number":["HK 98-039"]}],"id":[{"id":"10.13039\/501100003828","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    This study collected different probiotic isolates from animal and plant sources to evaluate the bile-salt hydrolase activity of probiotics\n                    <jats:italic>in vitro<\/jats:italic>\n                    . The deconjugation potential of bile acid was determined using high-performance liquid chromatography. HepG2 cells were cultured with probiotic strains with high BSH activity. The triglyceride (TG) and apolipoprotein B (apo B) secretion by HepG2 cells were evaluated. Our results show that the BSH activity and bile-acid deconjugation abilities of\n                    <jats:italic>Pediococcus acidilactici<\/jats:italic>\n                    NBHK002,\n                    <jats:italic>Bifidobacterium adolescentis<\/jats:italic>\n                    NBHK006,\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    NBHK007, and\n                    <jats:italic>Lactobacillus acidophilus<\/jats:italic>\n                    NBHK008 were higher than those of the other probiotic strains. The cholesterol concentration in cholesterol micelles was reduced within 24\u2009h. NBHK007 reduced the TG secretion by 100% after 48\u2009h of incubation. NBHK002, NBHK006, and NBHK007 could reduce apo B secretion by 33%, 38%, and 39%, respectively, after 24\u2009h of incubation. The product PROBIO S-23 produced a greater decrease in the total concentration of cholesterol, low-density lipoprotein, TG, and thiobarbituric acid reactive substance in the serum or livers of hamsters with hypercholesterolemia compared with that of hamsters fed with a high-fat and high-cholesterol diet. These results show that the three probiotic strains of lactic acid bacteria are better candidates for reducing the risk of cardiovascular disease.\n                  <\/jats:p>","DOI":"10.1155\/2014\/690752","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T16:03:46Z","timestamp":1415030626000},"page":"1-10","source":"Crossref","is-referenced-by-count":121,"title":["Cholesterol-Lowering Potentials of Lactic Acid Bacteria Based on Bile-Salt Hydrolase Activity and Effect of Potent Strains on Cholesterol Metabolism\n                    <i>In Vitro<\/i>\n                    and\n                    <i>In Vivo<\/i>"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6604-4768","authenticated-orcid":true,"given":"Cheng-Chih","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Food Science and Technology, Hungkuang University, No. 1018, Section 6, Taiwan Boulevard, Shalu District, Taichung City 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