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Both animal studies and human population-based and clinical studies have suggested that chronic stress is a risk factor for metabolic disorders. A good social support system is known to exert positive effects on the mental and physical well-being of an individual. On the other hand, long-term deprivation of social contacts may represent a stressful condition that has negative effects on health. In the present study, we investigated the effects of chronic social isolation on metabolic parameters in adult C57BL\/6 mice. We found that individually housed mice had increased adipose mass compared to group-housed mice, despite comparable body weight. The mechanism for the expansion of white adipose tissue mass was depot-specific. Notably, food intake was reduced in the social isolated animals, which occurred around the light-dark phase transition periods. Similarly, reductions in heat generated and the respiratory exchange ratio were observed during the light-dark transitions. These phase-specific changes due to long-term social isolation have not been reported previously. Our study shows social isolation contributes to increased adiposity and altered metabolic functions.<\/jats:p>","DOI":"10.1155\/2014\/690950","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T21:13:53Z","timestamp":1417036433000},"page":"1-9","source":"Crossref","is-referenced-by-count":24,"title":["Metabolic Effects of Social Isolation in Adult C57BL\/6 Mice"],"prefix":"10.1155","volume":"2014","author":[{"given":"Meng","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics and the Comprehensive Cancer Center, The Ohio State University, 912 Biomedical Research Tower, 460 West 12th Avenue, Columbus, OH 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics and the Comprehensive Cancer Center, The Ohio State University, 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