{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:26:11Z","timestamp":1765545971612,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Laboratory of the Medicinal Plants, Health and Galenic Formulation of the Department of Biological Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Experiments were carried out to validate the use of<jats:italic>F. glumosa<\/jats:italic>extract as a diuretic in the treatment of hypertension as claimed by traditional healers. The experiments were performed under the same conditions with two synthetic pharmacological diuretics considered as check (Furosemide and Amiloride hydrochlorothiazide). The aqueous extract leaves of<jats:italic>F. glumosa<\/jats:italic>accelerated the elimination of overloaded fluid. At the maximum of diuretic response, urinary osmolarity decreased significantly when compared with controls. The single dose treatment of the aqueous extract leaves of<jats:italic>F. glumosa<\/jats:italic>has significantly increased urine volume 24\u2009h after administration of the extract. The stability of aldosterone level, the absence of correlation with the plasma levels of sodium, and the increased clearance of free water in the animals receiving the extract show that increased diuresis and natriuresis moderate elevation are tubular in origin. The increase in Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup>, and Cl<jats:sup>\u2212<\/jats:sup>induced by the extract caused alkalinization of the urine and showed a strong inhibitory effect of carbonic anhydrase and saluretic. These effects were mainly observed at the dose of 375\u2009mg\/kg. These observations confirm the traditional use in the treatment of hypertension and support the importance of the conservation of local knowledge as well as the conservation of Cameroonian biodiversity.<\/jats:p>","DOI":"10.1155\/2014\/693803","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T17:57:07Z","timestamp":1413309427000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Diuretic Activity of the Aqueous Extract Leaves of<i>Ficus glumosa<\/i>Del. (Moraceae) in Rats"],"prefix":"10.1155","volume":"2014","author":[{"given":"Fid\u00e8le","family":"Ntchapda","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaound\u00e9r\u00e9, P.O. Box 454, Ngaound\u00e9r\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Djedouboum Abakar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaound\u00e9r\u00e9, P.O. Box 454, Ngaound\u00e9r\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blaise","family":"Kom","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science, University of Ngaound\u00e9r\u00e9, P.O. Box 454, Ngaound\u00e9r\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1473-5214","authenticated-orcid":true,"given":"Paulin","family":"Nana","sequence":"additional","affiliation":[{"name":"School of Wood, Water and Natural Resources, Faculty of Agriculture and Agricultural Sciences, University of Dschang, Ebolowa Campus, P.O. Box 786, Ebolowa, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Bonabe","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaound\u00e9r\u00e9, P.O. Box 454, Ngaound\u00e9r\u00e9, Cameroon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Maguirgue Kakesse","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, University of Ngaound\u00e9r\u00e9, P.O. 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