{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:06:49Z","timestamp":1740157609408,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["89-01-01-2476"],"award-info":[{"award-number":["89-01-01-2476"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme Research"],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Alopecia areata (AA) is a chronic inflammatory disease of the hair follicle. The exact pathogenesis of AA remains unknown, although recent studies support a T-cell mediated autoimmune process. On the other hand, some studies have proposed that the renin-angiotensin-aldosterone system (RAAS) may play a role in autoimmunity. Therefore, we assessed serum activity of angiotensin converting enzyme (ACE), a component of this system, in AA.<jats:italic>Methods<\/jats:italic>. ACE activity was measured in the sera of 19 patients with AA and 16 healthy control subjects. In addition, the relationship between severity and duration of the disease and ACE activity was evaluated.<jats:italic>Results<\/jats:italic>. Serum ACE activity was higher in the patient group (55.81\u2009U\/L) compared to the control group (46.41\u2009U\/L), but the difference was not statistically significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.085<\/mml:mn><\/mml:math>). Also, there was no correlation between ACE activity and severity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.13<\/mml:mn><\/mml:math>) and duration of disease (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.25<\/mml:mn><\/mml:math>) in the patient group.<jats:italic>Conclusion<\/jats:italic>. The increased serum ACE activity found in this study may demonstrate local involvement of the RAAS in the pathogenesis of AA. Assessment of ACE in a study with a larger sample size as well as in tissue samples is recommended in order to further evaluate the possible role of RAAS in AA.<\/jats:p>","DOI":"10.1155\/2014\/694148","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T21:02:50Z","timestamp":1412197370000},"page":"1-4","source":"Crossref","is-referenced-by-count":6,"title":["Angiotensin Converting Enzyme Activity in Alopecia Areata"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mohammad Reza","family":"Namazi","sequence":"first","affiliation":[{"name":"Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz 71348 44119, Iran"},{"name":"Department of Dermatology, Shiraz University of Medical Sciences, Shiraz 71348 44119, Iran"},{"name":"University of New South Wales, Sydney, NSW 2052, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2224-6602","authenticated-orcid":true,"given":"Armaghan","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz 71348 44119, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farhad","family":"Handjani","sequence":"additional","affiliation":[{"name":"Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz 71348 44119, Iran"},{"name":"Department of Dermatology, Shiraz University of Medical Sciences, Shiraz 71348 44119, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Eftekhar","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center, Department of Biochemistry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas 79149 64153, 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