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Chronic inflammation was induced by i.p. administration of CCl\n                    <jats:sub>4<\/jats:sub>\n                    0.5\u2009\n                    <jats:italic>\u03bc<\/jats:italic>\n                    L\/g of body weight through two injections a week for 6 weeks. DEC (50\u2009mg\/kg) was administered by gavage for 12 days before finishing the CCl\n                    <jats:sub>4<\/jats:sub>\n                    induction. Histological analyses of the DEC-treated group exhibited reduced inflammatory process and prevented liver necrosis and fibrosis. Immunohistochemical and immunofluorescence analyses of the DEC-treated group showed reduced COX-2, IL1\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mrow>\n                        <mml:mi>\u03b2<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    , MDA, TGF-\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                      <mml:mrow>\n                        <mml:mi>\u03b2<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    , and\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                      <mml:mrow>\n                        <mml:mi>\u03b1<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    SMA immunopositivity, besides exhibiting decreased IL1\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                      <mml:mrow>\n                        <mml:mi>\u03b2<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    , COX-2, NF\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                      <mml:mrow>\n                        <mml:mi>\u03ba<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    B, IFN\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                      <mml:mrow>\n                        <mml:mi>\u03b3<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    , and TGF\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                      <mml:mrow>\n                        <mml:mi>\u03b2<\/mml:mi>\n                      <\/mml:mrow>\n                    <\/mml:math>\n                    expressions in the western blot analysis. The DEC group enhanced significantly the IL-10 expression. The reduction of hepatic injury in the DEC-treated group was confirmed by the COX-2 and iNOS mRNA expression levels. Based on the results of the present study, DEC can be used as a potential anti-inflammatory drug for chronic hepatic inflammation.\n                  <\/jats:p>","DOI":"10.1155\/2014\/696383","type":"journal-article","created":{"date-parts":[[2014,10,13]],"date-time":"2014-10-13T17:03:19Z","timestamp":1413219799000},"page":"1-15","source":"Crossref","is-referenced-by-count":26,"title":["Diethylcarbamazine Reduces Chronic Inflammation and Fibrosis in Carbon Tetrachloride- (CCl\n                    <sub>\n                      <b>4<\/b>\n                    <\/sub>\n                    -) Induced Liver Injury in Mice"],"prefix":"10.1155","volume":"2014","author":[{"given":"Sura Wanessa Santos","family":"Rocha","sequence":"first","affiliation":[{"name":"Laboratory of Ultrastructure, Aggeu Magalh\u00e3es Research Center (CPqAM), Avenida Professor Moraes Rego, s\/n, Cidade Universit\u00e1ria, 50740-465 Recife, PE, Brazil"},{"name":"Department of Entomology, Aggeu Magalh\u00e3es Research 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