{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:50:43Z","timestamp":1792043443837,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"The Swedish Psoriasis Association"},{"DOI":"10.13039\/501100007949","name":"The Swedish Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To analyse levels of S100A8\/S100A9 (calprotectin) and selected cytokines, in blood, in patients with psoriatic arthritis (PsA).<jats:italic>Methods<\/jats:italic>. Sixty-five patients with PsA were examined for clinical manifestations and laboratory measurements of S-calprotectin, ESR, hs-CRP, and selected cytokines. Thirty-two patients had mono-\/oligoarthritis and 33 had polyarthritis. S-calprotectin, hs-CRP, and cytokines were measured using ELISA, immunoturbidimetry, and multiplex technology (Bio-Plex). Patients with PsA were compared with 31 healthy controls.<jats:italic>Results<\/jats:italic>. S-calprotectin and hs-CRP levels were significantly higher in patients with PsA compared with controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>, resp.). Patients suffering a polyarthritic disease pattern presented with significantly higher levels of S-calprotectin compared with controls and patients with mono-\/oligoarthritis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.017<\/mml:mn><\/mml:math>, resp.). The levels of S-calprotectin correlated with hs-CRP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.441<\/mml:mn><\/mml:math>), swollen joint count (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.397<\/mml:mn><\/mml:math>), and CXCL10 (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.046<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:msub><mml:mrow><mml:mi>r<\/mml:mi><\/mml:mrow><mml:mrow><mml:mi>s<\/mml:mi><\/mml:mrow><\/mml:msub><mml:mo>=<\/mml:mo><mml:mn>0.678<\/mml:mn><\/mml:math>) but not with any of the other cytokines evaluated. In multiple logistic regression analysis, S-calprotectin was the only variable significantly associated with psoriatic arthritis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.006<\/mml:mn><\/mml:math>, 95% CI = 1.002\u20131.010).<jats:italic>Conclusion<\/jats:italic>. S-calprotectin and hs-CRP levels were significantly higher in patients with PsA. A polyarthritic disease pattern showed higher levels of S-calprotectin than mono-\/oligoarthritis. S-calprotectin is considered a potential marker of disease activity in patients with PsA.<\/jats:p>","DOI":"10.1155\/2014\/696415","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T05:28:46Z","timestamp":1400477326000},"page":"1-5","source":"Crossref","is-referenced-by-count":58,"title":["S-Calprotectin (S100A8\/S100A9): A Potential Marker of Inflammation in Patients with Psoriatic Arthritis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5953-3213","authenticated-orcid":true,"given":"Claes","family":"Hansson","sequence":"first","affiliation":[{"name":"Department of Public Health and Clinical Medicine\/Rheumatology, Ume\u00e5 University, 901 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology\/Clinical Immunology, Ume\u00e5 University, 901 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd-Marie","family":"Alenius","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine\/Rheumatology, Ume\u00e5 University, 901 87 Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(73)90035-8"},{"issue":"1","key":"2","first-page":"120","volume":"27","year":"2009","journal-title":"Clinical and Experimental Rheumatology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.032482"},{"issue":"1","key":"4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.12659\/PJR.883763","volume":"78","year":"2013","journal-title":"Polish Journal of Radiology"},{"issue":"10","key":"5","first-page":"2089","volume":"34","year":"2007","journal-title":"Journal of Rheumatology"},{"issue":"6143","key":"6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/330080a0","volume":"330","year":"1987","journal-title":"Nature"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338501"},{"issue":"3","key":"8","first-page":"245","volume":"53","year":"2004","journal-title":"Physiological Research"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/art.20631"},{"issue":"6","key":"10","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1248\/bpb.26.753","volume":"26","year":"2003","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/00365520701416709"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg385"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.02.049"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0189-9"},{"key":"15","doi-asserted-by":"publisher","DOI":"10. 1007\/s12016-012-8306-2"},{"key":"16","doi-asserted-by":"publisher","DOI":"10. 1007\/s12016-012-8309-z"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3858\/emm.2008.40.2.237"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8307-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1080\/000155599750011679"},{"key":"20","doi-asserted-by":"publisher","DOI":"10. 3109\/08916934. 2013. 873413"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1186\/ar3781"},{"issue":"1","key":"22","first-page":"22","volume":"27","year":"2009","journal-title":"Clinical and Experimental Rheumatology"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/985301"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0943"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/art.21972"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/696415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/696415.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/696415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T23:30:17Z","timestamp":1589239817000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2014\/696415\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":25,"alternative-id":["696415","696415"],"URL":"https:\/\/doi.org\/10.1155\/2014\/696415","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}