{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T22:30:34Z","timestamp":1769380234673,"version":"3.49.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>A 63-year-old Caucasian woman developed severe<jats:italic>Plasmodium falciparum<\/jats:italic>malaria when travelling back from Cameroun. No antimalarial chemoprophylaxis had been observed. The patient was immediately admitted to the intensive care unit after evidence of multiple organ failure (coma, shock, acute respiratory distress syndrome, acute renal failure, etc.). However, initial parasitemia was less than 1%. The patient was managed by intravenous quinine and norepinephrine infusion due to refractory shock. The patient developed as an early complication ischemic lesions of both arms and feet. In addition to laboratory changes consistent with disseminated intravascular coagulation, there was also evidence for a low activity of the von Willebrand factor (VWF) cleaving protease ADAMTS13. Later complications included repeated candidemia and bacteraemia despite appropriate therapy; the origin appeared to be diffuse ischemic injury of the gastrointestinal tract. The patient ultimately recovered, but quadriamputation was necessary to treat symmetrical peripheral gangrene (SPG). In severe<jats:italic>Plasmodium falciparum<\/jats:italic>malaria, ischemic changes may be due to microvascular obstruction, but, in patients with low parasitemia, other endothelial factors may also be involved as observed in other groups of thrombotic microangiopathies.<\/jats:p>","DOI":"10.1155\/2014\/696725","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T17:24:40Z","timestamp":1397064280000},"page":"1-4","source":"Crossref","is-referenced-by-count":5,"title":["<i>Plasmodium falciparum<\/i>Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia"],"prefix":"10.1155","volume":"2014","author":[{"given":"Emeline","family":"Masse","sequence":"first","affiliation":[{"name":"D\u00e9partement des Soins Intensifs, Universit\u00e9 Catholique de Louvain, Cliniques Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3352","authenticated-orcid":true,"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[{"name":"D\u00e9partement des Soins Intensifs, Universit\u00e9 Catholique de Louvain, Cliniques Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium"},{"name":"Louvain Centre for Toxicology and Applied Pharmacology, Universit\u00e9 Catholique de Louvain, Cliniques Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium"},{"name":"Department of Intensive Care, Cliniques Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/0976-9668.107323","volume":"4","year":"2013","journal-title":"Journal of Natural Science, Biology and Medicine"},{"issue":"7","key":"2","first-page":"449","volume":"59","year":"2011","journal-title":"Journal of Association of Physicians of India"},{"key":"3","volume":"10, article 46","year":"2011","journal-title":"The Pan African Medical Journal"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-481X.2010.00697.x"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1684\/abc.2009.0367"},{"issue":"4","key":"6","first-page":"589","volume":"39","year":"2008","journal-title":"Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70129-4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.2006.44.2.139"},{"issue":"7","key":"9","first-page":"733","volume":"47","year":"1999","journal-title":"Journal of Association of Physicians of India"},{"key":"10","first-page":"498","volume":"52","year":"2004","journal-title":"Journal of Association of Physicians of India"},{"key":"11","first-page":"297","volume":"3","year":"2002","journal-title":"Journal, Indian Academy of Clinical Medicine"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03329.x"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-003-0984-5"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-04-0223"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(93)90131-9"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01826.x"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013236"},{"issue":"3","key":"18","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1093\/clinids\/24.3.430","volume":"24","year":"1997","journal-title":"Clinical Infectious Diseases"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2014\/696725.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2014\/696725.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2014\/696725.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T07:18:30Z","timestamp":1498115910000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/crim\/2014\/696725\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"alternative-id":["696725","696725"],"URL":"https:\/\/doi.org\/10.1155\/2014\/696725","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"value":"1687-9627","type":"print"},{"value":"1687-9635","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}