{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T18:19:23Z","timestamp":1778869163233,"version":"3.51.4"},"reference-count":11,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology Research and Practice"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Topical agents can be unpleasant due to long-term therapies in patients with moderate to severe seborrheic dermatitis. Systemic antifungal therapy is another alternative in treatment.<jats:italic>Aim<\/jats:italic>. This study was conducted to compare the efficacy of oral fluconazole and terbinafine in the treatment of moderate to severe seborrheic dermatitis.<jats:italic>Methods<\/jats:italic>. 64 patients with moderate to severe seborrheic dermatitis (SD) were enrolled in a randomized, parallel-group study. One study group took terbinafine 250\u2009mg daily (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>32<\/mml:mn><\/mml:mrow><\/mml:math>) and the other one fluconazole 300\u2009mg (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>32<\/mml:mn><\/mml:mrow><\/mml:math>) weekly for four weeks. Seborrheic dermatitis area severity index (SDASI) and the intensity of itching were calculated before, at the end of treatment, and two weeks after treatment.<jats:italic>Results<\/jats:italic>. Both drugs significantly reduced the severity of seborrheic dermatitis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). Multivariate linear regression revealed that efficacy of terbinafine is more than fluconazole (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI (0.63\u20134.7)). Moreover, each index of SD severity reduced 0.9 times after treatment. (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI (0.8\u20131.02)). The itching rate significantly diminished (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>); however, there was no difference between these two drugs statistically.<jats:italic>Conclusions<\/jats:italic>. Both systemic antifungal therapies may reduce the severity index of SD. However, terbinafine showed more reduction in the intensity of the disease. In other words, the more the primary intensity of the disease is, the more its reduction will be. This trial is resgistered with<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/results?term=201102205871N1\">201102205871N1<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2014\/705402","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T21:03:36Z","timestamp":1392757416000},"page":"1-5","source":"Crossref","is-referenced-by-count":10,"title":["Comparison the Efficacy of Fluconazole and Terbinafine in Patients with Moderate to Severe Seborrheic Dermatitis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Narges","family":"Alizadeh","sequence":"first","affiliation":[{"name":"Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamed","family":"Monadi Nori","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javad","family":"Golchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriar S.","family":"Eshkevari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehsan","family":"Kazemnejad","sequence":"additional","affiliation":[{"name":"Department of Preventive and Community Medicine, Guilan University of Medical Sciences, Rasht, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Darjani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht 41448, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","volume-title":"Seborrheic dermatitis","volume":"23","year":"2010"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200708040-00005"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00693.x"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00316.x"},{"key":"5","volume-title":"Seborrheic dermatitis","year":"2008"},{"issue":"1","key":"6","first-page":"39","volume":"48","year":"2006","journal-title":"Folia Medica"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04144.x"},{"issue":"11","key":"8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1046\/j.1365-4362.2002.01672.x","volume":"41","year":"2002","journal-title":"International Journal of Dermatology"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02123.x"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/039463200501800418","volume":"18","year":"2005","journal-title":"International journal of immunopathology and pharmacology"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.09.016"}],"container-title":["Dermatology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2014\/705402.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2014\/705402.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/drp\/2014\/705402.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T08:06:41Z","timestamp":1498118801000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/drp\/2014\/705402\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":11,"alternative-id":["705402","705402"],"URL":"https:\/\/doi.org\/10.1155\/2014\/705402","relation":{},"ISSN":["1687-6105","1687-6113"],"issn-type":[{"value":"1687-6105","type":"print"},{"value":"1687-6113","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}