{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:56:08Z","timestamp":1772042168693,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"crossref","award":["07010150023"],"award-info":[{"award-number":["07010150023"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"crossref","award":["0991019"],"award-info":[{"award-number":["0991019"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Foundation for Chronic Respiratory Disease of Chinese Medical Association","award":["07010150023"],"award-info":[{"award-number":["07010150023"]}]},{"name":"Special Foundation for Chronic Respiratory Disease of Chinese Medical Association","award":["0991019"],"award-info":[{"award-number":["0991019"]}]},{"name":"Youth Science Fund of Guangxi Zhuang Autonomous Region in China","award":["07010150023"],"award-info":[{"award-number":["07010150023"]}]},{"name":"Youth Science Fund of Guangxi Zhuang Autonomous Region in China","award":["0991019"],"award-info":[{"award-number":["0991019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases.<jats:italic>Objective<\/jats:italic>. To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients with NCFB under steady state.<jats:italic>Methods<\/jats:italic>. The study involved an open-label design in 52 eligible Chinese patients with NCFB, who were assigned to control (receiving no treatment) and roxithromycin (receiving 150\u2009mg\/day for 6 months) groups. At baseline and 6 months, the inflammatory markers such as interleukin- (IL-)8, neutrophil elastase (NE), matrix metalloproteinase- (MMP)9, hyaluronidase (HA), and type IV collagen in sputum were measured, along with the detection of dilated bronchus by throat computed tomography scan, and assessed the exacerbation.<jats:italic>Results<\/jats:italic>. Forty-three patients completed the study. The neutrophil in the sputum was decreased in roxithromycin group compared with control<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0<\/mml:mn><mml:mn>5<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. IL-8, NE, MMP-9, HA, and type IV collagen in sputum were also decreased in roxithromycin group compared with the control group (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>. Airway thickness of dilated bronchus and exacerbation were reduced in roxithromycin group compared with the control (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0<\/mml:mn><mml:mn>5<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>.<jats:italic>Conclusions<\/jats:italic>. Roxithromycin can reduce airway inflammation and airway thickness of dilated bronchus in patients with NCFB.<\/jats:p>","DOI":"10.1155\/2014\/708608","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T21:03:03Z","timestamp":1415134983000},"page":"1-14","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Low-Dose, Long-Term Roxithromycin on Airway Inflammation and Remodeling of Stable Noncystic Fibrosis Bronchiectasis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-0015","authenticated-orcid":true,"given":"Jifeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoning","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianghong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Respiratory Disease, Tenth Affiliated Hospital of Guangxi Medical University, Qinzhou 535000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dengjun","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tenth Affiliated Hospital of 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