{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:16:53Z","timestamp":1759515413486,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Aim.<\/jats:italic>To describe 7 years of activity of \u201cCROMa\u201d (Coordination of Research on Osteonecrosis of the Jaws) project of \u201cSapienza\u201d University of Rome.<jats:italic>Materials and Methods.<\/jats:italic>A preventive and therapeutic care pathway was created for patients with bisphosphonates (BPs) exposure. Demographic, social, behavioural, pharmacological, and clinical variables were registered in a dedicated database.<jats:italic>Results.<\/jats:italic>In the project, 502 patients, 403 females and 99 males, were observed. Bone pathologies were 79% osteometabolic diseases (OMD) and 21% metastatic cancer (CA). Females were 90% in OMD group and 41% in CA. BP administration was 54% oral, 31% IV, and 11% IM; 89% of BPs were amino-BP and 11% non-amino-BP. Consistently with bone pathology (OMD\/CA), alendronate appears to be prevalent for OMD (40% relative), while zoledronate was indicated in 92% of CA patients. Out of 502 cases collected, 28 BRONJ were detected: 17 of them were related to IV BP treatment. Preventive oral assessment was required for 50% of CA patients and by 4% of OMD patients.<jats:italic>Conclusions.<\/jats:italic>The proposed care pathway protocols for BP exposed patients appeared to be useful to meet treatment and preventive needs, in both oncological and osteometabolic diseases patients. Patients\u2019 and physicians\u2019 prevention awareness can be the starting point of a multilevel prevention system.<\/jats:p>","DOI":"10.1155\/2014\/719478","type":"journal-article","created":{"date-parts":[[2014,9,22]],"date-time":"2014-09-22T17:01:52Z","timestamp":1411405312000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["The \u201cCROMa\u201d Project: A Care Pathway for Clinical Management of Patients with Bisphosphonate Exposure"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mauro","family":"Capocci","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, 6 Caserta Street, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, 6 Caserta Street, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Cocco","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Pharmacy and Department of Surgery, Microsurgery and Medicine Sciences, University of Sassari, Viale S. Pietro, 07100 Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-9990","authenticated-orcid":true,"given":"Isabella","family":"Bignozzi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, 6 Caserta Street, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Annibali","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, 6 Caserta Street, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7390-4316","authenticated-orcid":true,"given":"Livia","family":"Ottolenghi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, 6 Caserta Street, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200507073530120"},{"first-page":"36","volume-title":"Biopsy principles and techniques","year":"2002","key":"3"},{"key":"4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.joms.2006.11.003","volume":"65","year":"2007","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.01.009"},{"issue":"5","key":"6","first-page":"417","volume":"73","year":"2007","journal-title":"Journal of the Canadian Dental Association"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2005.0110"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/107690"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.11.012"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708601101"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21130"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2007.08.040"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2006.06.004"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.14219\/jada.archive.2006.0355","volume":"137","year":"2006","journal-title":"The Journal of the American Dental Association"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.8670"},{"issue":"7","key":"17","first-page":"968","volume":"91","year":"2006","journal-title":"Haematologica"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.2465"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-033571"},{"issue":"2","key":"20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3816\/CLM.2008.n.013","volume":"8","year":"2008","journal-title":"Clinical Lymphoma & Myeloma"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500341173"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06230.x"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl163"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.10.061"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-010-0907-7"},{"issue":"2","key":"27","first-page":"103","volume":"22","year":"2011","journal-title":"Italian Journal of Maxillofacial Surgery"},{"year":"2013","key":"28"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2010.2835"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1097\/ID.0b013e3181cec8bc"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-6343.2009.01472.x"}],"container-title":["International Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2014\/719478.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2014\/719478.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ijd\/2014\/719478.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T16:51:48Z","timestamp":1498150308000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ijd\/2014\/719478\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":30,"alternative-id":["719478","719478"],"URL":"https:\/\/doi.org\/10.1155\/2014\/719478","relation":{},"ISSN":["1687-8728","1687-8736"],"issn-type":[{"type":"print","value":"1687-8728"},{"type":"electronic","value":"1687-8736"}],"subject":[],"published":{"date-parts":[[2014]]}}}