{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:52:42Z","timestamp":1777521162909,"version":"3.51.4"},"reference-count":38,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Eye Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background\/Aims.<\/jats:italic>To assess the effect of intravitreal bevacizumab injection (IVBI) for the treatment of macular edema due to infectious and noninfectious uveitides.<jats:italic>Design.<\/jats:italic>Retrospective interventional case series.<jats:italic>Methods.<\/jats:italic>A chart review was performed on all the patients who were diagnosed with uveitic macular edema (UME) and received 1.25\u2009mg of IVBI at two referral centers in Riyadh, Saudi Arabia. All included patients had their visual acuity and macular thickness analyzed at baseline and at 1 and 3 months following IVBI and any sign of reactivation was noted.<jats:italic>Results.<\/jats:italic>The mean age of patients was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn fontstyle=\"italic\">41<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">16<\/mml:mn><\/mml:math>years with a mean followup of<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mn fontstyle=\"italic\">4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">1<\/mml:mn><\/mml:math>months. Ten patients had idiopathic intermediate uveitis, 9 patients had Behcet\u2019s disease, 10 had idiopathic panuveitis, and twelve patients had presumed ocular tuberculosis uveitis. Following IVBI, the mean LogMAR visual acuity improved from<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mn fontstyle=\"italic\">0.8<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.8<\/mml:mn><\/mml:math>at baseline to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn fontstyle=\"italic\">0.4<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.5<\/mml:mn><\/mml:math>at 1 month and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn fontstyle=\"italic\">0.3<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">0.5<\/mml:mn><\/mml:math>at 3 months (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.002<\/mml:mn><\/mml:math>, at 3 months). The mean macular thickness was<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mn fontstyle=\"italic\">430<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">132<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m at baseline. Following IVBI macular thickness improved to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn fontstyle=\"italic\">286<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">93<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m at 1 month and to<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mn fontstyle=\"italic\">265<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn fontstyle=\"italic\">88<\/mml:mn><\/mml:math>\u2009<jats:italic>\u03bc<\/jats:italic>m at 3 months of followup (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn fontstyle=\"italic\">0.001<\/mml:mn><\/mml:math>, at 3 months).<jats:italic>Conclusion.<\/jats:italic>Bevacizumab was effective in the management of UME associated with both infectious and noninfectious uveitides. Intravitreal bevacizumab induced remission of UME with infectious uveitis and had no immunosuppressive effect against infectious agents.<\/jats:p>","DOI":"10.1155\/2014\/729465","type":"journal-article","created":{"date-parts":[[2014,7,21]],"date-time":"2014-07-21T17:12:44Z","timestamp":1405962764000},"page":"1-6","source":"Crossref","is-referenced-by-count":16,"title":["The Effects of Intravitreal Bevacizumab in Infectious and Noninfectious Uveitic Macular Edema"],"prefix":"10.1155","volume":"2014","author":[{"given":"Hassan","family":"Al-Dhibi","sequence":"first","affiliation":[{"name":"King Khaled Eye Specialist Hospital, Al-Oruba Street, P.O. Box 7191, Riyadh 11462, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issam H.","family":"Hamade","sequence":"additional","affiliation":[{"name":"The Eye Center and the Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Al-Halafi","sequence":"additional","affiliation":[{"name":"King Khaled Eye Specialist Hospital, Al-Oruba Street, P.O. Box 7191, Riyadh 11462, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maan","family":"Barry","sequence":"additional","affiliation":[{"name":"King Khaled Eye Specialist Hospital, Al-Oruba Street, P.O. Box 7191, Riyadh 11462, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel Bou","family":"Chacra","sequence":"additional","affiliation":[{"name":"The Eye Center and the Eye Foundation for Research in Ophthalmology, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishali","family":"Gupta","sequence":"additional","affiliation":[{"name":"King Khaled Eye Specialist Hospital, Al-Oruba Street, P.O. 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