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In order to perform the experiment, forty newborn piglets were subjected to normocapnic hypoxia and reoxygenation and were randomly allocated in 4 groups resuscitated with different oxygen concentrations, 18%, 21%, 40%, and 100%, respectively. Urine metabolic profiles at baseline and at hypoxia were analysed by<jats:sup>1<\/jats:sup>H-NMR spectroscopy and metabolites were also identified by multivariate statistical analysis. Metabolic pathways associations were also built up by ingenuity pathway analysis (IPA). Bioinformatics analysis of metabolites characterized the effect of metabolism in the 4 groups; it showed that the 21% of oxygen is the most \u201cphysiological\u201d and appropriate concentration to be used for resuscitation. Our data indicate that resuscitation with 21% of oxygen seems to be optimal in terms of survival, rapidity of resuscitation, and metabolic profile in the present animal model. These findings need to be confirmed with metabolomics in human and, if so, the knowledge of the perinatal asphyxia condition may significantly improve.<\/jats:p>","DOI":"10.1155\/2014\/731620","type":"journal-article","created":{"date-parts":[[2014,2,18]],"date-time":"2014-02-18T21:03:41Z","timestamp":1392757421000},"page":"1-7","source":"Crossref","is-referenced-by-count":25,"title":["Metabolomics Network Characterization of Resuscitation after Normocapnic Hypoxia in a Newborn Piglet Model Supports the Hypothesis That Room Air Is Better"],"prefix":"10.1155","volume":"2014","author":[{"given":"V.","family":"Fanos","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, 09042 Cagliari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Noto","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, 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