{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:09:56Z","timestamp":1772773796855,"version":"3.50.1"},"reference-count":28,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Cushing\u2019s syndrome (CS) may alter the performance of the hypothalamic-hypophyseal-thyroid axis. We searched for a relationship between hypercortisolism and primary thyroid disorders. The medical records of 40 patients with CS were retrospectively examined. Thyroid ultrasonography (USG), basal thyroid function test results (TFT), and antithyroglobulin and antithyroperoxidase antibodies were analyzed. In 80 control subjects, matched by age and gender with CS patients, thyroid USG, TFTs, and autoantibody panel were obtained. Among the CS patients, 17 had nodular goiter, versus 24 controls (42.5% versus 30%,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Among the twenty-five patients with an available TFT and autoantibody panel\u2014before and after surgical curative treatment\u2014autoantibody positivity was detected in 2 (8%) patients before and 3 (12%) after surgery (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.48<\/mml:mn><\/mml:math>). Regarding TFT results, 1 (2.5%) patient had subclinical hyperthyroidism and 1 (2.5%) had subclinical hypothyroidism, whereas 1 (2.5%) control had hyperthyroidism. In total, 21 (52.5%) patients and 32 (40%) controls had<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mo>\u2265<\/mml:mo><\/mml:mrow><\/mml:math>1 of the features of thyroid disorder, including goiter, positive thyroid autoantibody, and thyroid function abnormality; the difference was not significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>&gt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). The prevalence of primary thyroid disorders is not significantly increased in patients with CS.<\/jats:p>","DOI":"10.1155\/2014\/732736","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T01:16:38Z","timestamp":1399338998000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Primary Thyroid Disorders in Patients with Endogenous Hypercortisolism: An Observational Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"Eda Demir","family":"Onal","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10\/6, Ceyhun At\u0131f Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Sacikara","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10\/6, Ceyhun At\u0131f Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Saglam","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10\/6, Ceyhun At\u0131f Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reyhan","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10\/6, Ceyhun At\u0131f Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bekir","family":"Cakir","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Yildirim Beyazit University Medical School Ataturk Teaching and Research Hospital, Bilkent, Sokak No. 10\/6, Ceyhun At\u0131f Kansu Caddesi 1268, Ehlibeyt Mahallesi, 06520 Balgat, Cankaya, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"issue":"4","key":"1","first-page":"435","volume":"20","year":"1999","journal-title":"Endocrine Reviews"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.0954-6820.1953.tb15710.x","volume":"144","year":"1953","journal-title":"Acta Medica Scandinavica"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1507\/endocrj1954.31.577","volume":"31","year":"1984","journal-title":"Endocrinologia 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