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However, cutaneous adverse events are common due to the interference of epidermal growth factor receptor (EGFR) signaling in the skin. Cutaneous toxicities lead to poor compliance, drug cessation, and psychosocial discomfort. This paper summarizes the current knowledge concerning the presentation and management of skin toxicity from EGFRI. The common dermatologic adverse events are papulopustules and xerosis. Less common findings are paronychia, regulatory abnormalities of hair growth, maculopapular rash, mucositis, and postinflammatory hyperpigmentation. Radiation enhances EGFRI rash due to synergistic toxicity. There is a positive correlation between the occurrence and severity of cutaneous adverse effects and tumor response. To date, prophylactic systemic tetracycline and tetracycline class antibiotics have proven to be the most effective treatment regime.<\/jats:p>","DOI":"10.1155\/2014\/734249","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T08:00:44Z","timestamp":1393833644000},"page":"1-8","source":"Crossref","is-referenced-by-count":72,"title":["Epidermal Growth Factor Receptor Inhibitors: A Review of Cutaneous Adverse Events and Management"],"prefix":"10.1155","volume":"2014","author":[{"given":"K.","family":"Chanprapaph","sequence":"first","affiliation":[{"name":"Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Rajthevi, Bangkok 10400, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vachiramon","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 270 Rama VI Road, Rajthevi, Bangkok 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