{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:10:14Z","timestamp":1790485814748,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T00:00:00Z","timestamp":1412035200000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"},{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Esp\u00edrito Santo"},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Hypertension"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>\n                    The purpose was to determine the role of renal nerves in mediating the effects of antihypertensive treatment with\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arginine in a renovascular hypertension model. The 2K1C (two\u2010kidney one\u2010clip model) hypertensive rats were submitted to bilateral surgical\u2010pharmacological renal denervation. The animals were subdivided into six experimental groups: normotensive control rats (SHAM), 2K1C rats, 2K1C rats treated with\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arginine (2K1C\u2009+\u2009\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg), denervated normotensive (DN) rats, denervated 2K1C (2K1C\u2009+\u2009DN) rats, and denervated 2K1C\u2009+\u2009\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg (2K1C\u2009+\u2009DN\u2009+\u2009\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg) rats. Arterial blood pressure, water intake, urine volume, and sodium excretion were measured. The 2K1C rats exhibited an increase in the mean arterial pressure (MAP) (from 106 \u00b1 3 to 183 \u00b1 5.8\u2009mmHg,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.01), whereas\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg treatment induced a reduction in the MAP (143 \u00b1 3.4\u2009mmHg) without lowering it to the control level. Renal nerve denervation reduced the MAP to normotensive levels in 2K1C rats with or without chronic\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg treatment.\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg and denervation induced increases in water intake and urine volume, and\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg caused a significant natriuretic effect. Our results suggest that renal sympathetic activity participates in the genesis and the maintenance of the hypertension and also demonstrate that treatment with\n                    <jats:italic>L<\/jats:italic>\n                    \u2010arg alone is incapable of normalizing the MAP and that the effect of such treatment is not additive with the effect of kidney denervation.\n                  <\/jats:p>","DOI":"10.1155\/2014\/735627","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T17:06:20Z","timestamp":1412096780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of Renal Nerves in the Treatment of Renovascular Hypertensive Rats with\n                    <i>L<\/i>\n                    \u2010Arginine"],"prefix":"10.1155","volume":"2014","author":[{"given":"Sonia Alves","family":"Gouvea","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata V.","family":"Tiradentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cintia H.","family":"Santuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius","family":"Mengal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrique de A.","family":"Futuro Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyam F.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucia R.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,30]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.2174\/157340206778132590"},{"key":"e_1_2_8_2_2","first-page":"I-166","article-title":"Importance of the renal nerves in established two-kidney, one clip Goldblatt hypertension","volume":"4","author":"Katholi R. E.","year":"1982","journal-title":"Hypertension"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2009.09.019"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2009.05267.x"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.11.005"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.1.75"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.278.1.F138"},{"key":"e_1_2_8_8_2","first-page":"786","article-title":"Role of norepinephrine & angiotensin II in the neural control of renal sodium & water handling in spontaneously hypertensive rats","volume":"131","author":"Salman I. M.","year":"2010","journal-title":"Indian Journal of Medical Research"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2011.11.005"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.09.003"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12171"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.199356"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00241.2012"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.302522"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1349630"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.12.254"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90518.2008"},{"key":"e_1_2_8_18_2","first-page":"215","article-title":"Neural control of renin release","volume":"48","author":"Zanchetti A.","year":"1975","journal-title":"Clinical Science and Molecular Medicine"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/112_2008_1"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.246"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V561369"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003000700017"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05437.x"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.90529.2008"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365590410018774-1"},{"key":"e_1_2_8_26_2","first-page":"F322","article-title":"Renal nerves in renal adaptation to dietary sodium restriction","volume":"245","author":"DiBona G. F.","year":"1983","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00633"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.2.649"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199512020-00004"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(00)00225-9"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.19.2537"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00546.x"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.055475"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.041632"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2008.046565"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00908.2010"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.4199\/C00034ED1V01Y201106ISP022"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283449529"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2009000200010"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1081\/CEH-200031837"}],"container-title":["International Journal of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2014\/735627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/2014\/735627","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2014\/735627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:45:25Z","timestamp":1782848725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2014\/735627"}},"subtitle":[],"editor":[{"given":"Markus","family":"Schlaich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1155\/2014\/735627"],"URL":"https:\/\/doi.org\/10.1155\/2014\/735627","archive":["Portico"],"relation":{},"ISSN":["2090-0384","2090-0392"],"issn-type":[{"value":"2090-0384","type":"print"},{"value":"2090-0392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"2014-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"735627"}}