{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:38:39Z","timestamp":1761597519380},"reference-count":27,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Patients with rheumatoid arthritis (RA) have a higher risk for atherosclerosis. There is no clinical information about scavenger receptor CD36 and the development of subclinical atherosclerosis in patients with RA. The aim of this study was to evaluate the association between membrane expression of CD36 in peripheral blood mononuclear cells (PBMC) and carotid intima-media thickness (cIMT) in patients with RA.<jats:italic>Methods<\/jats:italic>. We included 67 patients with RA from the Rheumatology Department of Hospital Civil \u201cDr. Juan I. Menchaca,\u201d Guadalajara, Jalisco, Mexico. We evaluated the cIMT, considering subclinical atherosclerosis when &gt;0.6\u2009mm. Since our main objective was to associate the membrane expression of CD36 with subclinical atherosclerosis, other molecules related with cardiovascular risk such as ox-LDL, IL-6, and TNF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>were tested.<jats:italic>Results<\/jats:italic>. We found low CD36 membrane expression in PBMC from RA patients with subclinical atherosclerosis (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). CD36 mean fluorescence intensity had negative correlations with cIMT (<jats:italic>r<\/jats:italic>= \u22120.578,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), ox-LDL (<jats:italic>r<\/jats:italic>= \u22120.427,<jats:italic>P<\/jats:italic>= 0.05), TNF<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>(<jats:italic>r<\/jats:italic>= \u22120.729,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>), and IL-6 (<jats:italic>r<\/jats:italic>= \u22120.822,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. RA patients with subclinical atherosclerosis showed low membrane expression of CD36 in PBMC and increased serum proinflammatory cytokines. Further studies are needed to clarify the regulation of CD36 in RA.<\/jats:p>","DOI":"10.1155\/2014\/736786","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T21:22:50Z","timestamp":1402348970000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["Low Levels of CD36 in Peripheral Blood Monocytes in Subclinical Atherosclerosis in Rheumatoid Arthritis: A Cross-Sectional Study in a Mexican Population"],"prefix":"10.1155","volume":"2014","author":[{"given":"Eduardo","family":"G\u00f3mez-Ba\u00f1uelos","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n en Reumatolog\u00eda y del Sistema Musculo Esquel\u00e9tico, Centro Universitario de Ciencias de la Salud, Benem\u00e9rita Universidad de Guadalajara, Sierra Mojada No. 950, Colonia Independencia, 44340 Guadalajara, JAL, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz 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