{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:53:27Z","timestamp":1771494807897,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T00:00:00Z","timestamp":1417651200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Scholarly Research Notices"],"published-print":{"date-parts":[[2014,12,4]]},"abstract":"<jats:p><jats:italic>Caralluma<\/jats:italic>is a plant that possessing a great therapeutic potential in folk medicine in Yemen, namely,<jats:italic>Caralluma penicillata<\/jats:italic>(<jats:italic>C. penicillata<\/jats:italic>) as antiulcer. The study aims to evaluate the anti-inflammatory properties and gastritis protection activity of<jats:italic>C. penicillata<\/jats:italic>against indomethacin in adult guinea pigs. The study was divided into four parts: firstly, the optimum dose of extract as anti-inflammatory effect was determined. Secondly, the acute anti-inflammatory effect of extract were estimated. Thirdly, the repeated doses of extract against chronic inflammation was estimated. The anti-inflammatory activity of extract was compared with indomethacin as a prototype of drug against inflammation. Fourthly, the gastritis protection properties of extract with\/without indomethacin were performed. The results showed that a 400\u2009mg\/kg of 10% ethanol extract produced the maximum of anti-inflammatory effect. Also, the single dose of extract was equipotent for indomethacin (10\u2009mg\/kg), but shorter in duration with regard to acute anti-inflammatory effect. In addition, the repeated doses of extract against chronic inflammation were less potent than indomethacin with regard to ulcerogenic effect. On the other hand, extract-indomethacin combination reduced the gastritis effect of indomethacin based on ulcer index and histological study.<\/jats:p>","DOI":"10.1155\/2014\/738493","type":"journal-article","created":{"date-parts":[[2014,12,4]],"date-time":"2014-12-04T21:02:20Z","timestamp":1417726940000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of Pharmacological Activity of<i>Caralluma penicillata<\/i>: Anti-Inflammatory Properties and Gastritis Protection against Indomethacin in Adult Guinea Pigs"],"prefix":"10.1155","volume":"2014","author":[{"given":"Nabil","family":"Albaser","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"},{"name":"Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najeeb","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"},{"name":"Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohanad","family":"Shehab","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Al-Adhal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, Sana\u2019a University, Sana\u2019a, Yemen"},{"name":"Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0791-8602","authenticated-orcid":true,"given":"Mohammed","family":"Amood AL-Kamarany","sequence":"additional","affiliation":[{"name":"Tihama Foundation for Drug Studies and Research, Hodeidah, Yemen"},{"name":"Department of Pharmacy Practice, Faculty of Clinical Pharmacy, Hodeidah University, P.O. 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