{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:22:07Z","timestamp":1778901727462,"version":"3.51.4"},"reference-count":98,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The role of oxidative stress in different aortopathies is evaluated. Thirty-two tissue samples from 18 men and 14 women were divided into: 4 control (C) subjects, 11 patients with systemic arterial hypertension (SAH), 4 with variants of Marfan\u2019s syndrome (MV), 9 with Marfan\u2019s syndrome (M), 2 with Turner\u2019s syndrome, and 2 with Takayasu\u2019s arteritis (TA). Aorta fragments were homogenized. Lipoperoxidation (LPO), copper-zinc and manganese superoxide dismutase (Mn and Cu-Zn-SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), endothelial nitric oxide synthase (eNOS), nitrates and nitrites (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>NO<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>NO<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>), and type IV collagen, and laminin were evaluated. There was an increase in Mn- and Cu-Zn-SOD activity in SAH, MV, M, and Turner\u2019s syndrome. There was also an increase in CAT activity in M and Turner\u2019 syndrome. GPx and GST activity decreased and LPO increased in all groups. eNOS was decreased in SAH, MV, and M and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>NO<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>3<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:msup><mml:mrow><mml:msub><mml:mrow><mml:mtext>NO<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><\/mml:msup><\/mml:mrow><\/mml:math>were increased in SAH and TA. Type IV collagen was decreased in Turner\u2019s syndrome and TA. Laminin<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>-1 was decreased in MV and increased in M. In conclusion, similarities and differences in oxidative stress in the different aortopathies studied including pathologies with aneurysms were found with alterations in SOD, CAT, GPx, GST, and eNOS activity that modify subendothelial basement membrane proteins.<\/jats:p>","DOI":"10.1155\/2014\/760694","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T08:55:33Z","timestamp":1404291333000},"page":"1-13","source":"Crossref","is-referenced-by-count":42,"title":["Analysis of Oxidative Stress Enzymes and Structural and Functional Proteins on Human Aortic Tissue from Different Aortopathies"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mar\u00eda Elena","family":"Soto","sequence":"first","affiliation":[{"name":"Immunology Department, National Institute of Cardiology \u201cIgnacio Chavez\u201d, Juan Badiano 1, Secci\u00f3n XVI, Tlalpan, 14080 Mexico City, DF, 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