{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T03:06:31Z","timestamp":1772507191300,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Oral biopsy aims to obtain clear and safe diagnosis; it can be performed by scalpel or laser. The controversy in this latter application is the thermal alteration due to tissue heating. The aim of this study is the histological evaluation of margins of \u201c<jats:italic>in vivo<\/jats:italic>\u201d biopsies collected by diode and KTP lasers.<jats:italic>Material and Methods<\/jats:italic>. 17 oral benign lesions biopsies were made by diode 808\u2009nm (SOL, DenMatItalia, Italy) and KTP 532\u2009nm (SmartLite, DEKA, Italy). Samples were observed at OM LEICA DM 2000; margin alterations were evaluated through Leica Application Suite 3.4.<jats:italic>Results<\/jats:italic>. Epithelial and connective damages were assessed for each pathology with an average of 0.245\u2009mm and a standard deviation of \u00b10.162\u2009mm in mucoceles, 0.382\u2009mm \u00b1 0.149\u2009mm in fibromas, 0.336\u2009mm \u00b1 0.106\u2009mm in hyperkeratosis, 0.473\u2009mm \u00b1 0.105\u2009mm in squamous hyperplasia, 0.182\u2009mm in giant cell granuloma, and 0.149\u2009mm in melanotic macula.<jats:italic>Discussion<\/jats:italic>. The histologic aspect of lesions influenced the response to laser, whereas the greater inflammation and cellularity were linked with the higher thermal signs. Many artifacts were also associated to histologic procedures.<jats:italic>Conclusion<\/jats:italic>. Both tested lasers permitted sure histologic diagnosis. However, it is suggested to enlarge biopsies of about 0.5\u2009mm, to avoid thermal alterations, especially in inflammatory lesions like oral lichen planus.<\/jats:p>","DOI":"10.1155\/2014\/761704","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T17:06:40Z","timestamp":1414429600000},"page":"1-6","source":"Crossref","is-referenced-by-count":22,"title":["Biopsy of Different Oral Soft Tissues Lesions by KTP and Diode Laser: Histological Evaluation"],"prefix":"10.1155","volume":"2014","author":[{"given":"Umberto","family":"Romeo","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8509-2255","authenticated-orcid":true,"given":"Gaspare","family":"Palaia","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Lo Giudice","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9278-8872","authenticated-orcid":true,"given":"Alessandro","family":"Del Vecchio","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences, \u201cSapienza\u201d University of Rome, Via Caserta 6, 00161 Rome, 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